{"id":"W1985690440","doi":"10.1016/j.vascn.2004.06.002","title":"Cholemic transgenic mice: A novel animal model to investigate the effects of bile acids","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacological and Toxicological Methods","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Yükseköğretim Kurulu; Council for Higher Education; William P. Clements Center for Southwest Studies, Southern Methodist University","keywords":"TBARS; Thiobarbituric acid; Lipid peroxidation; Hepatocyte; Genetically modified mouse; Malondialdehyde; Bile acid; Cholestasis; Bile Salt Export Pump; In vivo; Enterohepatic circulation; Oxidative stress; Transgene; Internal medicine; Pharmacology; Biology; Chemistry; Biochemistry; Medicine; In vitro; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007154812,0.001595824,0.0007513536,0.002258323,0.0009035906,0.001019882,0.0009211659,0.001734997,0.003725232],"category_scores_gemma":[0.0004028985,0.0007558985,0.0006303876,0.0005183798,0.001345076,0.001084133,0.0006657569,0.00332585,0.001159892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147541,"about_ca_system_score_gemma":0.000542057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007828257,"about_ca_topic_score_gemma":0.001913431,"domain_scores_codex":[0.9995153,0.00009658002,0.00007057756,0.0001081872,0.0001220747,0.00008731439],"domain_scores_gemma":[0.9991754,0.000160448,0.0002396435,0.0001077945,0.00007341953,0.0002433844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005464558,0.0002548685,0.0002644091,0.00005697296,0.00001577346,0.000269411,0.00005657279,0.00007623273,0.9958775,0.0013031,0.000199516,0.001079152],"study_design_scores_gemma":[0.0003891972,0.001323948,0.001773492,0.00004603415,0.0001460344,0.001802149,0.0001706834,0.001587755,0.9808686,0.001331756,0.01052077,0.00003950422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386802,0.002726226,0.0446749,0.002589477,0.0004989257,0.0005176975,0.004351908,0.001265007,0.004695567],"genre_scores_gemma":[0.9281821,0.004826876,0.03771146,0.0008254102,0.0002297754,0.001083079,0.00369276,0.000661095,0.02278737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003725232,"threshold_uncertainty_score":0.01246214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05492315649669883,"score_gpt":0.3989918791136595,"score_spread":0.3440687226169607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}