{"id":"W1985697930","doi":"10.1016/j.euroneuro.2014.01.009","title":"Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications","year":2014,"lang":"en","type":"review","venue":"European Neuropsychopharmacology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Chromatin; Biology; DNA methylation; Gene; Genetics; Disease; Epigenesis; Phenotype; Neuroscience; Mechanism (biology); Computational biology; Bioinformatics; Gene expression; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005360873,0.0006527326,0.0009409441,0.0001853208,0.0002296084,0.00006233624,0.0008790348,0.000261026,0.00004165343],"category_scores_gemma":[0.0001025627,0.0006370479,0.0007087904,0.0002163328,0.0001681565,0.000002668894,0.0002406041,0.0003267057,0.00009306645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002441736,"about_ca_system_score_gemma":0.0001080717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001294422,"about_ca_topic_score_gemma":0.000006974026,"domain_scores_codex":[0.995806,0.00141628,0.0008986351,0.001162127,0.0001143541,0.0006025738],"domain_scores_gemma":[0.9979602,0.0001744777,0.0006230964,0.000908593,0.0001344406,0.0001992336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003296599,0.000146284,0.00001451963,0.001360423,0.0002803471,0.000001769466,0.00001836293,0.0000502249,0.02122723,0.0001694316,0.004693777,0.9720047],"study_design_scores_gemma":[0.0007102518,0.0005049983,0.0003593055,0.0001149679,0.0005950473,0.000009755347,0.000001522265,0.00003245069,0.00003560818,0.0001261662,0.9969141,0.0005957697],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000112318,0.9736837,0.0180161,0.0001665958,0.001330832,0.001840247,0.0001601113,0.0001026039,0.004587528],"genre_scores_gemma":[0.001961008,0.9922999,0.0008428071,0.0008082839,0.001751319,0.0002454622,0.001064389,0.0004946524,0.0005321528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922204,"threshold_uncertainty_score":0.9996081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0637042604436896,"score_gpt":0.3800741589662475,"score_spread":0.3163698985225579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}