{"id":"W1985698425","doi":"10.1634/stemcells.2007-0724","title":"Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction","year":2008,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Institute of Medical Science, University of Tokyo; Hospital for Sick Children; University of Toronto","keywords":"Biology; Side population; Population; Stromal cell; Stem cell; Hypoxia (environmental); Cancer research; Bone marrow; Hox gene; Cell biology; Pathology; Cancer stem cell; Immunology; Chemistry; Genetics; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751483,0.0001437947,0.0001552919,0.00002338347,0.0002461015,0.00002776698,0.0001012607,0.00007110072,0.000008385069],"category_scores_gemma":[0.00001820194,0.0001133342,0.00005527415,0.0000719676,0.00007554668,0.0000121839,0.00004959468,0.0000807473,0.00000860362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001741946,"about_ca_system_score_gemma":0.00006057816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004616848,"about_ca_topic_score_gemma":0.0001397595,"domain_scores_codex":[0.9990679,0.0001221731,0.0001889868,0.0002924363,0.0001372867,0.000191205],"domain_scores_gemma":[0.9994814,0.00004088238,0.0001398847,0.0002236744,0.00005124419,0.00006285551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000587033,0.00001624571,0.00160465,0.0000187768,0.00002169157,0.0000012848,0.00009778835,0.000006987207,0.9941881,0.000005765367,0.001949517,0.002030479],"study_design_scores_gemma":[0.0003363702,0.00006107742,0.01534993,0.00001607088,0.00003140368,0.00008653862,0.0002595779,0.00001092317,0.926596,0.00002676428,0.05703716,0.0001882054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904959,0.007900291,0.0001397491,0.00003353409,0.0007911926,0.0002276657,0.00002023216,0.00001253873,0.000378869],"genre_scores_gemma":[0.9954568,0.002445892,0.00006462527,0.0001976439,0.0008406428,0.00002257074,0.00004438898,0.00001894367,0.0009084765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06759213,"threshold_uncertainty_score":0.4621633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009222819131380953,"score_gpt":0.2186719338553859,"score_spread":0.2094491147240049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}