{"id":"W1985713600","doi":"10.1126/stke.12pe2","title":"Notch and Integrin Affinity: A Sticky Situation","year":2008,"lang":"en","type":"review","venue":"Science Signaling","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Notch signaling pathway; Cell biology; Notch proteins; Integrin; Hes3 signaling axis; Vitronectin; Biology; Hairless; Signal transduction; Cell fate determination; Effector; Cell adhesion; Cell; Fibronectin; Extracellular matrix; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003928872,0.0001841436,0.000289459,0.0001252967,0.000257441,0.00003320857,0.0002092427,0.0002162981,0.000006281542],"category_scores_gemma":[0.0001511852,0.0001503216,0.00007353665,0.0002854065,0.0004245132,0.000006843782,0.0001643566,0.0001151168,0.00001548906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002938896,"about_ca_system_score_gemma":0.0005384581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002603422,"about_ca_topic_score_gemma":0.000002805819,"domain_scores_codex":[0.9988782,0.00005294167,0.0002284112,0.0004850922,0.0001439286,0.0002114489],"domain_scores_gemma":[0.9995522,0.00002160237,0.000131676,0.0001621278,0.00006384766,0.00006856692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003359994,0.00001001729,0.0000147074,0.0002447257,0.00001931888,0.000001884923,0.00005218116,0.000006656751,0.02349711,0.00003474802,0.00004524748,0.97607],"study_design_scores_gemma":[0.0001626647,0.0001414394,0.00008015527,0.001509265,0.00008296347,0.0003043422,0.00005518936,0.00002821404,0.02220836,0.0001179188,0.9746787,0.0006308138],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00637971,0.9922735,0.0006225119,0.000008375926,0.0001925489,0.0002242845,0.000004649261,0.00001011091,0.0002843205],"genre_scores_gemma":[0.00731463,0.9907396,0.001485619,0.00003103278,0.0001249166,0.00001681489,0.0001184483,0.00001033155,0.0001585487],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9754393,"threshold_uncertainty_score":0.6129937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247526826270861,"score_gpt":0.3218376982918856,"score_spread":0.289362430029177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}