{"id":"W1985715054","doi":"10.1016/j.matbio.2010.06.005","title":"Mechanisms of emphysema in autosomal dominant cutis laxa","year":2010,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Tropoelastin; Cutis laxa; Elastin; Genetically modified mouse; Desmosine; Immunostaining; Pathology; Elastic fiber; Lung; Transgene; Chemistry; Endocrinology; Molecular biology; Biology; Medicine; Internal medicine; Immunohistochemistry; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392047,0.0001129897,0.0001926292,0.0001053837,0.00002443598,0.000003996734,0.0002527004,0.0002576461,0.0001607409],"category_scores_gemma":[0.0002244042,0.0001037957,0.00006726401,0.0001253488,0.0001442101,0.000001607378,0.000193713,0.0001610479,0.00002624546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006226021,"about_ca_system_score_gemma":0.00007381598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002584132,"about_ca_topic_score_gemma":0.001061666,"domain_scores_codex":[0.9990608,0.00008653642,0.000196352,0.0003075914,0.00005868736,0.0002900659],"domain_scores_gemma":[0.9994824,0.00002825525,0.00005878408,0.000320195,0.00006630131,0.00004407625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008935454,0.00007043766,0.009723795,0.00001264037,0.00001561342,0.00000404728,0.00002735261,0.00000138192,0.9773751,0.009896869,0.0001030506,0.00268028],"study_design_scores_gemma":[0.0009698187,0.000537222,0.02115852,0.000004717377,0.000004642628,0.00002133459,0.00007335733,0.00006545689,0.9587601,0.007033779,0.01119422,0.0001768632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965614,0.0002642808,0.001676048,0.0002543309,0.0001884722,0.0001974981,0.00002881873,0.000006102523,0.0008230611],"genre_scores_gemma":[0.9984574,0.00003674193,0.0009021678,0.00002799216,0.00004574018,0.00002838436,0.00005721374,0.00001427179,0.0004301026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01861511,"threshold_uncertainty_score":0.4232667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008140525116526645,"score_gpt":0.3128905614736651,"score_spread":0.3047500363571385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}