{"id":"W1985719186","doi":"10.1016/j.biotechadv.2010.02.003","title":"Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest","year":2010,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Recombinant DNA; Cell growth; Bioprocess; Cell cycle; Cell biology; Cell culture; Cell cycle checkpoint; Biology; Cell; Chemistry; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006731607,0.001617614,0.001793619,0.001578583,0.000304901,0.001044797,0.001284607,0.001113273,0.001584593],"category_scores_gemma":[0.0003878032,0.0005243067,0.0005687521,0.001957508,0.0008958226,0.001246127,0.0006853689,0.002687055,0.002343957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001230181,"about_ca_system_score_gemma":0.0006753171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137218,"about_ca_topic_score_gemma":0.001737865,"domain_scores_codex":[0.9998093,0.00001998105,0.00002005351,0.00004338839,0.00008345865,0.00002390232],"domain_scores_gemma":[0.9998043,0.00008612293,0.00003286206,0.00001258049,0.00004600031,0.00001804178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001326706,0.0001911516,0.0001810971,0.012542,0.00008805942,0.0003672031,0.00008063058,0.00107023,0.09080278,0.01162495,0.01668459,0.8662346],"study_design_scores_gemma":[0.00004514509,0.0001734646,0.000701679,0.0008211689,0.0001102692,0.001143595,0.0000432758,0.0003941361,0.03740054,0.003079106,0.956039,0.00004861182],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008457206,0.9930992,0.003211699,0.0002160312,0.000310088,0.00001815373,0.00005072021,0.00004493184,0.002203554],"genre_scores_gemma":[0.002912766,0.9919342,0.002928461,0.0001617819,0.0001214409,0.00003142603,0.0001344036,0.00001122911,0.00176422],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001793619,"threshold_uncertainty_score":0.008925617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182769873817193,"score_gpt":0.2863716949580217,"score_spread":0.2745439962198498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}