{"id":"W1985731766","doi":"10.1007/s10637-009-9375-9","title":"Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer","year":2009,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Cancer Research Society","keywords":"Sphingosine; Sphingosine kinase 1; Sphingosine-1-phosphate; Docetaxel; Sphingosine kinase; Breast cancer; Apoptosis; Pharmacology; Cancer research; Cancer; Cytotoxicity; Medicine; Systemic administration; Cancer cell; Kinase; Internal medicine; Chemistry; Biology; Cell biology; In vitro; Receptor; Biochemistry; In vivo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685023,0.0003562837,0.0002661131,0.0005595757,0.0002691962,0.0003623794,0.0002699315,0.0003953661,0.002396749],"category_scores_gemma":[0.0001430731,0.0001227152,0.0001383033,0.0003655717,0.0002234969,0.0003490223,0.0002653363,0.0006465856,0.0007047403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248354,"about_ca_system_score_gemma":0.0004267417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005684984,"about_ca_topic_score_gemma":0.001249514,"domain_scores_codex":[0.9999603,0.00001135946,0.000002855325,0.000005494931,0.000007898601,0.00001212602],"domain_scores_gemma":[0.9999616,0.00001039392,0.00000623081,0.000003023817,0.00000616426,0.00001261963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004420207,0.001088722,0.002009823,0.001314468,0.0000895864,0.002017682,0.0001709399,0.001450995,0.5910711,0.009792037,0.009246686,0.3773278],"study_design_scores_gemma":[0.001813205,0.008110269,0.006349573,0.0001631941,0.0003738069,0.004522352,0.0001706259,0.001715881,0.6713178,0.003049754,0.3023687,0.00004490936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5919272,0.3311576,0.007822847,0.01006447,0.001392126,0.0005283834,0.002080911,0.0004169939,0.05460959],"genre_scores_gemma":[0.8029369,0.1701079,0.005029058,0.00107366,0.0005706321,0.0001902592,0.001016326,0.00002642068,0.01904872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396749,"threshold_uncertainty_score":0.008017957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166985057428922,"score_gpt":0.2609885731992294,"score_spread":0.2493187226249402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}