{"id":"W1985764154","doi":"10.1086/426403","title":"CHEK2 Is a Multiorgan Cancer Susceptibility Gene","year":2004,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health","funders":"","keywords":"CHEK2; Multiorgan failure; Gene; Genetics; Medicine; Biology; Internal medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002816324,0.0001544866,0.00021677,0.00004789412,0.000148932,0.00002633418,0.0005163221,0.00004033513,0.00005088652],"category_scores_gemma":[0.00002426558,0.000116746,0.0001546712,0.0001688133,0.0005599737,0.000003090777,0.00009611157,0.0001743367,0.000005720469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482583,"about_ca_system_score_gemma":0.0004178889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000738732,"about_ca_topic_score_gemma":0.0001483464,"domain_scores_codex":[0.998885,0.00007627815,0.0003799269,0.000196253,0.0002380988,0.0002243955],"domain_scores_gemma":[0.9985507,0.000008882848,0.0005249082,0.0005029443,0.0003188273,0.00009377894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007768466,0.00007807053,0.005692188,0.000004594278,0.0001774673,0.000003739856,0.00101751,0.003782056,0.9771789,0.000008945837,0.001156022,0.01082281],"study_design_scores_gemma":[0.0009786632,0.001511463,0.03979714,0.00001730958,0.0001186883,0.0001304918,0.000742613,0.00000912235,0.9502193,0.0007405316,0.00548648,0.000248162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952049,0.002171069,0.001130223,0.001132201,0.000170907,0.0000975199,0.00001707804,0.000004233182,0.00007183044],"genre_scores_gemma":[0.9932644,0.0008690594,0.003679854,0.00126496,0.0007757121,0.000005773046,0.000003848652,0.00003262165,0.0001037153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03410495,"threshold_uncertainty_score":0.4760762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598810311857032,"score_gpt":0.3159356584831712,"score_spread":0.2999475553646009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}