{"id":"W1985764154","doi":"10.1086/426403","title":"CHEK2 Is a Multiorgan Cancer Susceptibility Gene","year":2004,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health","funders":"","keywords":"CHEK2; Multiorgan failure; Gene; Genetics; Medicine; Biology; Internal medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109337,0.000637337,0.000319224,0.0008847176,0.0005375005,0.000364343,0.000416401,0.0007221262,0.004590252],"category_scores_gemma":[0.0004161581,0.0001900395,0.00027586,0.0004430818,0.0003307942,0.0001782393,0.0003701753,0.0008483649,0.000651561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005950201,"about_ca_system_score_gemma":0.0002936583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387432,"about_ca_topic_score_gemma":0.001668684,"domain_scores_codex":[0.9998918,0.00001571481,0.000007204074,0.00003724198,0.00003069507,0.00001734167],"domain_scores_gemma":[0.999747,0.00006985737,0.00005828763,0.00001736928,0.000027206,0.00008036425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002384543,0.0002069124,0.0405855,0.0003088179,0.0003499473,0.03460449,0.0001200588,0.0008057395,0.8838094,0.002759637,0.007288006,0.02677703],"study_design_scores_gemma":[0.0006316108,0.0005607926,0.3685507,0.0001062608,0.0006714613,0.150517,0.0002997373,0.005483342,0.4057544,0.002818845,0.06448492,0.000120962],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978438,0.005097533,0.003534325,0.001879303,0.0003126728,0.00005177434,0.00220202,0.0003673548,0.008117041],"genre_scores_gemma":[0.9915324,0.0007382822,0.001169354,0.0001902552,0.00007997307,0.00002285381,0.001123475,0.00003578204,0.005107496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004590252,"threshold_uncertainty_score":0.01535589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598810311857032,"score_gpt":0.3159356584831712,"score_spread":0.2999475553646009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}