{"id":"W1985779248","doi":"10.1371/journal.ppat.1000474","title":"MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; Harvard University","keywords":"Mycobacterium tuberculosis; Microbiology; TLR2; Tuberculosis; Macrophage; CD14; Trehalose; Cytokine; Immunology; Biology; Medicine; Immune system; Innate immune system; Pathology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817382,0.0003616518,0.0002703781,0.000164588,0.0001635331,0.00037963,0.0001696113,0.0003540828,0.001339968],"category_scores_gemma":[0.000291285,0.0002097391,0.0002386175,0.00009484676,0.0002455672,0.0002414275,0.0003359999,0.0004972054,0.0007543593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132591,"about_ca_system_score_gemma":0.0002497089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004556969,"about_ca_topic_score_gemma":0.0005811584,"domain_scores_codex":[0.9997177,0.00004368921,0.00003553364,0.00004552908,0.00006514424,0.00009241035],"domain_scores_gemma":[0.9996216,0.00003336525,0.0001595521,0.0000370435,0.00003751338,0.0001108286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001148595,0.00001620881,0.0002850138,0.00001264809,0.000001311901,0.00004474688,0.000007151987,0.00001070516,0.9992482,0.00003313163,0.000007223633,0.0002188079],"study_design_scores_gemma":[0.00005888132,0.0005912257,0.03908388,0.00001319046,0.00002134957,0.001954972,0.0001325599,0.001535829,0.9530414,0.00008847988,0.003467917,0.00001026428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964108,0.000760699,0.001880345,0.00007133777,0.00002337821,0.00002007834,0.0001858115,0.00003444045,0.0006129859],"genre_scores_gemma":[0.9949772,0.0003575813,0.002025177,0.00005025644,0.00001565018,0.00004908265,0.0005298816,0.00002049694,0.001974665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339968,"threshold_uncertainty_score":0.004482627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133828434945186,"score_gpt":0.3072883137637497,"score_spread":0.2759500294142978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}