{"id":"W1985799363","doi":"10.1016/j.cell.2011.09.027","title":"The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine","year":2011,"lang":"en","type":"letter","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Biology; RIG-I; Innate immune system; RNA silencing; RNA; Interferon; Virology; MDA5; Immune system; Computational biology; RNA interference; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463993,0.0001912792,0.0002299062,0.00004817934,0.0002476874,0.00001251766,0.0003563634,0.0005643604,0.0001731593],"category_scores_gemma":[0.00002914765,0.00009923063,0.0001492648,0.00003832425,0.0005045426,0.00002225938,0.0001566969,0.001257635,0.0001552108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001622657,"about_ca_system_score_gemma":0.00003067407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002165389,"about_ca_topic_score_gemma":0.00003239758,"domain_scores_codex":[0.9989352,0.0003899812,0.0002120038,0.0001782996,0.00002692828,0.0002576487],"domain_scores_gemma":[0.999176,0.0001701674,0.0001947119,0.000419485,0.00003581988,0.000003782235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002902313,0.00002025248,0.00005267194,0.0000477222,0.0001341273,0.000005105857,0.0002597017,1.046757e-8,0.5925329,0.000008907244,0.4037107,0.002937748],"study_design_scores_gemma":[0.0002041632,0.0001007964,0.0003141621,0.00001708814,0.00003711571,0.00002486362,0.00002494291,2.529142e-7,0.4528803,0.0000134012,0.5463118,0.00007113655],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.645002,0.08929721,0.0001211357,0.1183289,0.02467757,0.001923687,0.0005419868,0.0001735749,0.1199339],"genre_scores_gemma":[0.8615892,0.0004339276,0.000001840822,0.01811414,0.0001150528,0.000007328813,0.00002836972,0.00002746937,0.1196826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165872,"threshold_uncertainty_score":0.546387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006734770866787518,"score_gpt":0.1932331795280732,"score_spread":0.1864984086612856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}