{"id":"W1985799363","doi":"10.1016/j.cell.2011.09.027","title":"The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine","year":2011,"lang":"en","type":"letter","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Biology; RIG-I; Innate immune system; RNA silencing; RNA; Interferon; Virology; MDA5; Immune system; Computational biology; RNA interference; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001905581,0.000684427,0.0008143204,0.0003298982,0.001266915,0.002447825,0.0009893388,0.01270897,0.004165595],"category_scores_gemma":[0.006620622,0.0004407905,0.0006712612,0.0001792126,0.00510912,0.004747763,0.001554321,0.01929871,0.003025225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00196777,"about_ca_system_score_gemma":0.0006665838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003657221,"about_ca_topic_score_gemma":0.000474633,"domain_scores_codex":[0.9987494,0.0005125818,0.00007056856,0.000174045,0.0003136555,0.0001797527],"domain_scores_gemma":[0.9980425,0.00123171,0.0001330593,0.0002562995,0.0001124292,0.0002240714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002124032,0.0001440576,0.001657696,0.0003107292,0.00007961618,0.009622137,0.0004956882,0.0006272665,0.01327317,0.139235,0.7422277,0.09020294],"study_design_scores_gemma":[0.0005225667,0.0002722522,0.001136191,0.0001903788,0.00003476683,0.008329539,0.0004530786,0.002515481,0.0135099,0.2333348,0.7395968,0.0001041665],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.007774833,0.02145561,0.003327359,0.9280019,0.02636055,0.00002811366,0.0001007115,0.0001721596,0.01277879],"genre_scores_gemma":[0.19802,0.01811947,0.003653752,0.6713566,0.07307151,0.0001951475,0.0001209564,0.0001047861,0.03535782],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01270897,"threshold_uncertainty_score":0.01427728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006734770866787518,"score_gpt":0.1932331795280732,"score_spread":0.1864984086612856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}