{"id":"W1985805476","doi":"10.1007/s00011-009-8166-2","title":"siRNA knocks down Hsp27 and increases angiotensin II-Induced phosphorylated NF-κB p65 levels in aortic smooth muscle cells","year":2009,"lang":"en","type":"article","venue":"Inflammation Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Hsp27; Angiotensin II; Phosphorylation; Proinflammatory cytokine; Heat shock protein; Gene knockdown; NF-κB; Vascular smooth muscle; IκB kinase; Cell biology; Small interfering RNA; Transfection; Signal transduction; Internal medicine; Chemistry; Endocrinology; Inflammation; Biology; Hsp70; Medicine; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657112,0.0005144312,0.0005209305,0.0004503941,0.0004213676,0.0004667989,0.0003397106,0.0003267973,0.00331842],"category_scores_gemma":[0.0001476484,0.0003748626,0.0006060468,0.0003591308,0.0005849479,0.0003118698,0.0003052258,0.001380451,0.0008181231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400398,"about_ca_system_score_gemma":0.0006352694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856473,"about_ca_topic_score_gemma":0.003081737,"domain_scores_codex":[0.9996866,0.00003335883,0.00004187587,0.00006516471,0.00005779983,0.000115273],"domain_scores_gemma":[0.9997446,0.00004485697,0.00004770831,0.00002910485,0.00002298993,0.0001107707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003027548,0.0000863798,0.00008777774,0.00006511527,0.00001637642,0.00005909125,0.00002285617,0.00004176656,0.9985148,0.0001249141,0.0002012094,0.0004769329],"study_design_scores_gemma":[0.0001119284,0.0003478469,0.00418861,0.000008909408,0.00005608602,0.0001938282,0.0001245101,0.0009066854,0.9912759,0.00007295218,0.002701318,0.00001137589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887654,0.0015415,0.004475457,0.0006306366,0.0003286841,0.00006002044,0.001387383,0.0002785767,0.002532297],"genre_scores_gemma":[0.985452,0.001683885,0.003285358,0.0002927607,0.00008366373,0.0001521336,0.001655443,0.00009338295,0.007301373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00331842,"threshold_uncertainty_score":0.01110125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920603093783029,"score_gpt":0.3389252616077716,"score_spread":0.2997192306699413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}