{"id":"W1985817833","doi":"10.1021/ol503432b","title":"Preparation of Conformationally Restricted β<sup>2,2</sup>- and β<sup>2,2,3</sup>-Amino Esters and Derivatives Containing an All-Carbon Quaternary Center","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Quaternary carbon; Center (category theory); Carbon fibers; Stereochemistry; Medicinal chemistry; Organic chemistry; Crystallography; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392232,0.000448946,0.0002503536,0.0001609192,0.0001307441,0.0002035684,0.0001904923,0.0002535351,0.001314995],"category_scores_gemma":[0.0002385981,0.000164894,0.0001393282,0.0001640452,0.0001584539,0.0003397792,0.0002208248,0.00050181,0.000609695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104236,"about_ca_system_score_gemma":0.0002242568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113516,"about_ca_topic_score_gemma":0.0002610785,"domain_scores_codex":[0.9999164,0.00001992144,0.000007862431,0.00002163523,0.00001805262,0.00001610027],"domain_scores_gemma":[0.9998378,0.00002596047,0.00005982893,0.000020785,0.00002417503,0.0000314473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006425907,0.00001349878,0.00005723584,0.00007609335,0.00000771792,0.00008042165,0.00002281314,0.0001407583,0.9951209,0.0002969754,0.00007638417,0.004042756],"study_design_scores_gemma":[0.00001127225,0.0001563691,0.0002853668,0.000005006938,0.000007489793,0.0001985025,0.000008241829,0.0002439996,0.9944112,0.00005965001,0.004605309,0.000007628497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630989,0.00361395,0.02375467,0.000143001,0.0001166549,0.0001635912,0.0006678715,0.0001991007,0.008242229],"genre_scores_gemma":[0.9550344,0.00416558,0.03282221,0.0001697138,0.00004683166,0.0001257101,0.0009290457,0.0001595767,0.006547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314995,"threshold_uncertainty_score":0.004399121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007797683645213577,"score_gpt":0.2329894133332867,"score_spread":0.2251917296880731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}