{"id":"W1985817833","doi":"10.1021/ol503432b","title":"Preparation of Conformationally Restricted β<sup>2,2</sup>- and β<sup>2,2,3</sup>-Amino Esters and Derivatives Containing an All-Carbon Quaternary Center","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Quaternary carbon; Center (category theory); Carbon fibers; Stereochemistry; Medicinal chemistry; Organic chemistry; Crystallography; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395626,0.0001714434,0.0002174822,0.00005035322,0.00005040485,0.00004396973,0.000115314,0.000105673,0.00001631426],"category_scores_gemma":[0.00009818583,0.0001550366,0.00004653915,0.00006294784,0.000113325,0.00002413357,0.00008493396,0.0000674922,9.484095e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001450143,"about_ca_system_score_gemma":0.00001625644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004699367,"about_ca_topic_score_gemma":0.000005693329,"domain_scores_codex":[0.9989538,0.00009997523,0.0003084542,0.0003117244,0.0001431386,0.0001828959],"domain_scores_gemma":[0.9994503,0.0000458913,0.0001480378,0.0002187944,0.00004447086,0.00009253996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009317919,0.00002989277,0.01356428,0.00002588649,0.0001347228,7.946367e-7,0.0007710074,0.000109326,0.9841622,0.0000161195,0.00009923517,0.0009933532],"study_design_scores_gemma":[0.002184707,0.0005973029,0.0130056,0.0000867794,0.0001864693,0.00003876181,0.0009187458,0.06059872,0.9194638,0.0000457363,0.002249595,0.0006238128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979944,0.00005629043,0.0009148087,0.0007947081,0.000008314887,0.00009927359,0.000009862581,0.00001203326,0.0001103019],"genre_scores_gemma":[0.9980802,0.00006818493,0.0003938343,0.001102834,0.00009107689,0.000004425613,0.0002252283,0.00001841067,0.00001581687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06469844,"threshold_uncertainty_score":0.6322209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007797683645213577,"score_gpt":0.2329894133332867,"score_spread":0.2251917296880731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}