{"id":"W1985825056","doi":"10.1189/jlb.1106681","title":"1α,25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in the<i>CD14</i>promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner","year":2007,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Infectious Diseases Centre","funders":"Canadian Institutes of Health Research","keywords":"Phosphatidylinositol; Biology; CREB; Kinase; Cell biology; Binding site; Molecular biology; Cancer research; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346172,0.0005023662,0.000354497,0.0004064884,0.0003541716,0.0004943127,0.000488419,0.0003136706,0.005182006],"category_scores_gemma":[0.0001512313,0.0002854632,0.0003890308,0.0002519947,0.0005855151,0.0001912733,0.0002815572,0.0009602325,0.001509727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008764204,"about_ca_system_score_gemma":0.0004636362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001893671,"about_ca_topic_score_gemma":0.003837022,"domain_scores_codex":[0.9995605,0.00004238205,0.00002774443,0.0001213571,0.0001446547,0.0001032942],"domain_scores_gemma":[0.9998854,0.00001465401,0.00002382976,0.00001887896,0.00001489704,0.00004230003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008308416,0.0000401904,0.0000554036,0.00004032543,0.000002911999,0.00002668774,0.0000101788,0.00002177027,0.9990479,0.00008685549,0.00007460426,0.0005100294],"study_design_scores_gemma":[0.00003498947,0.0001076369,0.002395839,0.00001045083,0.000007791416,0.0001247364,0.00003629914,0.0004096375,0.9912764,0.00004678359,0.005544392,0.00000503631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647306,0.002743324,0.01379307,0.000665101,0.0004660669,0.0002778472,0.004495165,0.0005821738,0.01224677],"genre_scores_gemma":[0.9413058,0.001759574,0.01492759,0.0003690182,0.00008279935,0.0002970066,0.006388193,0.0001315386,0.03473855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005182006,"threshold_uncertainty_score":0.01733553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161496723881979,"score_gpt":0.2795345450159434,"score_spread":0.2679195777771237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}