{"id":"W1985836396","doi":"10.1159/000335911","title":"Cyclin D1 Induction Preceding Neuronal Death via the Excitotoxic NMDA Pathway Involves Selective Stimulation of Extrasynaptic NMDA Receptors and JNK Pathway","year":2012,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"NMDA receptor; Neuroscience; Glutamate receptor; Biology; Neuroprotection; Cell biology; NBQX; Ionotropic effect; AMPA receptor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003021769,0.0003787437,0.000320972,0.0002280712,0.001206675,0.0001523348,0.000395758,0.00009036868,0.00005002744],"category_scores_gemma":[0.001588625,0.0002855606,0.0001211035,0.0008463114,0.0007856034,0.001107282,0.0002335238,0.0005431767,0.00001545414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004976049,"about_ca_system_score_gemma":0.0001530702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001180337,"about_ca_topic_score_gemma":0.000004065989,"domain_scores_codex":[0.9955594,0.001686166,0.0004359643,0.0008955303,0.0006985531,0.0007243972],"domain_scores_gemma":[0.997493,0.001409219,0.0002790662,0.0003218492,0.0001438026,0.0003530863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758839,0.0003784725,0.03388117,0.00002424294,0.000007654769,0.000005021931,0.00046302,0.0003890626,0.962023,0.0003348781,0.0001220184,0.00219559],"study_design_scores_gemma":[0.0004299779,0.0004844823,0.08255183,0.00001264269,0.00002706681,0.00001831228,0.00006466334,0.002233566,0.913592,0.000175882,0.0001746056,0.0002349526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966446,0.0001900078,0.0001814956,0.0001806662,0.001609249,0.000927022,0.00006962749,0.00009583574,0.000101487],"genre_scores_gemma":[0.9982424,0.0002520795,0.00001891153,0.0006559402,0.0004341359,0.0001626929,0.000005167753,0.0000511588,0.0001774712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04867066,"threshold_uncertainty_score":0.9999596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06463413416972692,"score_gpt":0.3227029228947882,"score_spread":0.2580687887250613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}