{"id":"W1985836747","doi":"10.1016/j.bpj.2013.11.218","title":"Occupancy of a Single Binding Site is Sufficient for AMPAR Activation","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"AMPA receptor; Ionotropic effect; Glutamate receptor; Biophysics; Chemistry; Ligand (biochemistry); Binding site; Ion channel; Patch clamp; Gating; Transmembrane domain; Ligand-gated ion channel; Neurotransmission; Ionotropic glutamate receptor; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007159482,0.0004196787,0.001340474,0.0003647483,0.0007909774,0.001159349,0.0008598858,0.000970651,0.006790955],"category_scores_gemma":[0.001594242,0.0008216121,0.0007112781,0.0001883235,0.0007400967,0.0009132117,0.001185791,0.001909325,0.002855848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005929176,"about_ca_system_score_gemma":0.001090354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001554397,"about_ca_topic_score_gemma":0.003724226,"domain_scores_codex":[0.9985898,0.0001723024,0.0001760922,0.0002714339,0.0003949935,0.0003954421],"domain_scores_gemma":[0.9970934,0.0006299756,0.0003252649,0.0004162765,0.0003667861,0.001168269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003359145,0.0001606051,0.0006783802,0.00006186924,0.00002711707,0.0001460415,0.00002460186,0.000121924,0.9959965,0.0005061126,0.0003467141,0.001594315],"study_design_scores_gemma":[0.0002045832,0.0009140793,0.02304405,0.00004232056,0.00009310795,0.003539906,0.0001779178,0.006536083,0.9567114,0.001559774,0.007060488,0.0001163464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838495,0.001027723,0.009547587,0.0006404955,0.0002652831,0.00008327125,0.0005322366,0.000526662,0.003527218],"genre_scores_gemma":[0.9932105,0.0001614447,0.004245498,0.0002565722,0.0000463613,0.00006157204,0.0005363312,0.0001513932,0.001330388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006790955,"threshold_uncertainty_score":0.02271807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08546217633972292,"score_gpt":0.3611361438268479,"score_spread":0.275673967487125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}