{"id":"W1985861853","doi":"10.1517/14728220802600707","title":"Regulation of the Na+/H+exchanger in the healthy and diseased myocardium","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Sodium–hydrogen antiporter; Extracellular; Intracellular; Ischemia; Gene isoform; Intracellular pH; Muscle hypertrophy; Cell biology; MAPK/ERK pathway; Chemistry; Kinase; Homeostasis; Phosphorylation; Reperfusion injury; Sodium-calcium exchanger; Internal medicine; Biochemistry; Biology; Endocrinology; Sodium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003099934,0.0005277305,0.0007626271,0.0001354108,0.0002172947,0.00002227755,0.0004485115,0.0005401986,0.0000358814],"category_scores_gemma":[0.00001897203,0.0003211483,0.0005373656,0.0002814629,0.0001979478,0.00001046648,0.00005240655,0.0002880681,0.000005645474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000552188,"about_ca_system_score_gemma":0.0002129059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001921827,"about_ca_topic_score_gemma":0.000002001984,"domain_scores_codex":[0.9972307,0.0006048626,0.0006777422,0.000633217,0.0004688837,0.0003845707],"domain_scores_gemma":[0.9985805,0.00006817961,0.000345911,0.0008418161,0.00007690158,0.0000866632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007730206,0.0006847372,0.0001877655,0.002515076,0.0005738523,0.000004984803,0.007059239,0.001016413,0.0002567442,0.0005071089,0.008606831,0.9778143],"study_design_scores_gemma":[0.0006893827,0.0002611996,0.0006471946,0.0008350756,0.00003449589,0.00002454299,0.000206013,0.0003953789,0.0001335943,0.00006308642,0.9963347,0.0003753559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004996618,0.9967499,0.0001376077,0.0007061624,0.0003770053,0.001329668,0.00007063756,0.00001606631,0.0001132532],"genre_scores_gemma":[0.04279108,0.9536747,0.00002485968,0.001142177,0.0007769985,0.0002416312,0.001151475,0.0000737162,0.0001233066],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9877278,"threshold_uncertainty_score":0.9999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03546406584183281,"score_gpt":0.3073342933687829,"score_spread":0.2718702275269501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}