{"id":"W1985864219","doi":"10.1056/nejmoa1411321","title":"Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma","year":2014,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1324,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Carfilzomib; Lenalidomide; Medicine; Dexamethasone; Multiple myeloma; Oncology; Proteasome inhibitor; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012333,0.0003526796,0.0008491093,0.000345709,0.0002126015,0.0002376437,0.0003257906,0.0004102707,0.001948542],"category_scores_gemma":[0.0008977024,0.0001069939,0.0005077227,0.0003143037,0.0003101746,0.0001572912,0.0001811458,0.000739561,0.0002350356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006736927,"about_ca_system_score_gemma":0.000678929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006768106,"about_ca_topic_score_gemma":0.002373797,"domain_scores_codex":[0.9996011,0.0001928022,0.00002987402,0.00005616624,0.00007266754,0.00004734505],"domain_scores_gemma":[0.9996624,0.0001074413,0.00008120603,0.00001700675,0.00001870412,0.0001132659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2190874,0.005779602,0.04005739,0.001840473,0.002099654,0.000854922,0.0001161456,0.002132666,0.01094565,0.0007334762,0.008500088,0.7078525],"study_design_scores_gemma":[0.3059684,0.2828933,0.3062409,0.0007546344,0.00388259,0.00680829,0.0001995877,0.005010855,0.008999147,0.002981653,0.07616528,0.00009537723],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9066323,0.08573885,0.0006831985,0.002846814,0.0005036562,0.000519369,0.0002975086,0.00006865072,0.002709603],"genre_scores_gemma":[0.9846455,0.01187643,0.0008895517,0.0007346635,0.00034183,0.0002402043,0.0003670832,0.000004734616,0.0008999894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948542,"threshold_uncertainty_score":0.006518483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03364004799786217,"score_gpt":0.3132240272849626,"score_spread":0.2795839792871004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}