{"id":"W1985891703","doi":"10.1074/jbc.m112.353748","title":"Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitin-conjugating enzyme; Cell division control protein 4; Cullin; Biochemistry; DNA ligase; Skp1; Chemistry; Biology; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001821358,0.0002200688,0.0002676055,0.00009947605,0.0001557539,0.0004319717,0.0001985328,0.0002077489,0.0009340144],"category_scores_gemma":[0.0001486028,0.0001762097,0.0001919257,0.0001185382,0.0001425694,0.0002052864,0.0003249463,0.0002801821,0.0004791191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005263168,"about_ca_system_score_gemma":0.0002024471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028084,"about_ca_topic_score_gemma":0.0007283374,"domain_scores_codex":[0.9998504,0.00001513885,0.000009573992,0.00004496118,0.00004030874,0.00003968892],"domain_scores_gemma":[0.9999219,0.000007096862,0.00001504407,0.00001242646,0.000009813995,0.00003380603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007610841,0.00001343191,0.000679417,0.00001888476,0.0000107751,0.00008194322,0.00001140682,0.0002230026,0.9977652,0.0001071053,0.00005132842,0.0009613512],"study_design_scores_gemma":[0.00001667876,0.00008688081,0.005864478,0.000003082308,0.000009779164,0.000313074,0.00002292374,0.002870384,0.9885013,0.00006319008,0.002241265,0.000006887578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963737,0.0004748292,0.002292246,0.0000385831,0.000008179348,0.000006516749,0.00005603666,0.00007199272,0.000677806],"genre_scores_gemma":[0.9971929,0.0002080531,0.001129206,0.00003970866,0.000003261786,0.000007819129,0.0001165283,0.00001396188,0.001288725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009340144,"threshold_uncertainty_score":0.00381875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07577510633570313,"score_gpt":0.3184750591870167,"score_spread":0.2426999528513136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}