{"id":"W1985903963","doi":"10.1529/biophysj.108.139741","title":"Molecular Mechanism of Ion-Ion and Ion-Substrate Coupling in the Na+-Dependent Leucine Transporter LeuT","year":2008,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Neurotransmitter transporter; Ion; Substrate (aquarium); Symporter; Binding site; Ion pump; Molecular dynamics; Biophysics; Coupling (piping); Lipid bilayer; Transporter; Membrane; Neurotransmitter; Computational chemistry; Receptor; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004568057,0.0003133648,0.0006660759,0.0002275327,0.0004677697,0.001255629,0.0007218297,0.0009837371,0.001046494],"category_scores_gemma":[0.0004207872,0.0002835942,0.0004077767,0.0001336046,0.0006504497,0.001582589,0.0004763081,0.000713353,0.000598458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006971639,"about_ca_system_score_gemma":0.0003007052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232228,"about_ca_topic_score_gemma":0.0002320218,"domain_scores_codex":[0.9998369,0.0000353935,0.00001748886,0.00003899914,0.00003833597,0.00003275371],"domain_scores_gemma":[0.9998229,0.00006098158,0.00003770358,0.00001695783,0.00002541397,0.00003608652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007698358,0.00008607892,0.0007116834,0.0002349221,0.00003929998,0.001058184,0.0001153392,0.002234824,0.9735974,0.01657734,0.0003460273,0.004228986],"study_design_scores_gemma":[0.0001968052,0.0006262604,0.003997682,0.00003617292,0.00005946918,0.002735319,0.000264411,0.09085224,0.8882298,0.007657563,0.00524231,0.0001019565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666323,0.00354557,0.02294114,0.002446203,0.0002219359,0.00008174788,0.0001626757,0.0003504399,0.003617998],"genre_scores_gemma":[0.9946848,0.001105574,0.00246141,0.0001208613,0.00003458695,0.00002185311,0.0001016417,0.00001661102,0.001452783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255629,"threshold_uncertainty_score":0.005058289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638254757397975,"score_gpt":0.2375856857164013,"score_spread":0.2212031381424215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}