{"id":"W1985915847","doi":"10.1021/cn100090g","title":"Cysteine Thioesters as Myelin Proteolipid Protein Analogues to Examine the Role of Butyrylcholinesterase in Myelin Decompaction","year":2010,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Mount Saint Vincent University","funders":"Pfizer Canada; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Canadian Institutes of Health Research; Alzheimer Society; Mount Saint Vincent University; Nova Scotia Health Research Foundation; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Butyrylcholinesterase; Myelin; Cysteine; Proteolipid protein 1; Chemistry; Biochemistry; Myelin proteolipid protein; Neuroscience; Myelin basic protein; Biology; Aché; Enzyme; Central nervous system; Acetylcholinesterase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002528815,0.0002404606,0.0003323681,0.0001742777,0.00006492162,0.0000424308,0.0003624673,0.00008072771,0.00001135193],"category_scores_gemma":[0.001853763,0.00016385,0.00008636704,0.0008158923,0.0002346822,0.0002100767,0.0001306377,0.0004795896,0.00002041932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002087797,"about_ca_system_score_gemma":0.0001200714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008617192,"about_ca_topic_score_gemma":0.00004297374,"domain_scores_codex":[0.9980239,0.00007400766,0.0004874026,0.000582164,0.0004728075,0.0003597741],"domain_scores_gemma":[0.9987137,0.0001022547,0.00012645,0.0005910972,0.0001611236,0.0003053349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002917458,0.0003277115,0.008380327,0.00002917249,0.000001634936,0.00002673988,0.0001544876,0.00001570871,0.9889456,0.00003905591,0.00002756336,0.001760258],"study_design_scores_gemma":[0.0007183708,0.0002729579,0.02209427,0.0000893429,0.00001707729,0.00009864863,0.00006441293,0.0004910735,0.9750981,0.00005526205,0.000846542,0.0001539152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959037,0.0000310375,0.00001431032,0.002498929,0.0001662921,0.001229762,0.00001768183,0.00004228055,0.00009601148],"genre_scores_gemma":[0.9962434,0.000007973818,0.0001847595,0.002993105,0.0002735659,0.0001474304,0.0000151297,0.00002258872,0.0001121064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01384746,"threshold_uncertainty_score":0.668161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226821300017411,"score_gpt":0.2897329712283272,"score_spread":0.2774647582281531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}