{"id":"W1985925082","doi":"10.1124/dmd.110.036160","title":"Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1)","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Efflux; P-glycoprotein; Metabolite; Multiple drug resistance; Transporter; Tamoxifen; Active metabolite; Pharmacology; Abcg2; ABCC1; Chemistry; Drug resistance; Biology; ATP-binding cassette transporter; Biochemistry; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148514,0.0002286605,0.0003773673,0.0003103003,0.0001968362,0.0004970116,0.0001473465,0.0003715745,0.001543793],"category_scores_gemma":[0.0004008694,0.0001169449,0.0001511517,0.00031622,0.0001725043,0.000230654,0.0002268268,0.0003456744,0.0006176052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003661798,"about_ca_system_score_gemma":0.0002248788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008671238,"about_ca_topic_score_gemma":0.001112247,"domain_scores_codex":[0.9998265,0.00004710259,0.000008480864,0.00002401066,0.00006988284,0.0000241266],"domain_scores_gemma":[0.9998215,0.00005366305,0.00006882768,0.000007296869,0.00002858349,0.0000202282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008600114,0.0001241699,0.01779799,0.0004531138,0.0001027844,0.00132761,0.0001335449,0.0006440337,0.7710921,0.00260225,0.003342983,0.2015194],"study_design_scores_gemma":[0.000249317,0.004022224,0.07521795,0.00009264163,0.0001641933,0.01290503,0.0002361287,0.002322768,0.7757867,0.0009877775,0.1279705,0.00004481814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252216,0.05048311,0.009896856,0.001866805,0.00009981557,0.00008815257,0.0009585024,0.000196603,0.01118854],"genre_scores_gemma":[0.9696354,0.01771752,0.002584754,0.0003162504,0.00007246044,0.00005107149,0.0007202554,0.00001814493,0.008884151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543793,"threshold_uncertainty_score":0.005164504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004063026521213674,"score_gpt":0.2099218176228959,"score_spread":0.2058587911016823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}