{"id":"W1985925082","doi":"10.1124/dmd.110.036160","title":"Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1)","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Efflux; P-glycoprotein; Metabolite; Multiple drug resistance; Transporter; Tamoxifen; Active metabolite; Pharmacology; Abcg2; ABCC1; Chemistry; Drug resistance; Biology; ATP-binding cassette transporter; Biochemistry; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004094014,0.0002650814,0.0005634489,0.00008133818,0.0001789351,0.0000151206,0.00021992,0.0001240294,0.0000814587],"category_scores_gemma":[0.00001812789,0.0001427371,0.0003261661,0.000353878,0.0004534406,0.0001809234,0.00001782307,0.0004166688,0.000002105732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006251056,"about_ca_system_score_gemma":0.00008527355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001232345,"about_ca_topic_score_gemma":0.0003096901,"domain_scores_codex":[0.9982596,0.00007992158,0.0005359726,0.0003378365,0.0005109824,0.000275671],"domain_scores_gemma":[0.9986823,0.00005426165,0.0003248958,0.000621852,0.0002027303,0.0001139199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298894,0.0002965053,0.002161622,0.0003989766,0.000187114,0.000007361889,0.007481025,0.000001714957,0.9625751,0.02307564,0.0001186799,0.00239735],"study_design_scores_gemma":[0.001500846,0.00001120841,0.3472589,0.000119929,0.000645293,0.000008891257,0.0003981594,0.00001444477,0.6434004,0.00157032,0.004940592,0.0001309816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935609,0.001624237,0.0001961059,0.001874516,0.0005044387,0.000926886,0.0003209812,0.00002448792,0.0009674456],"genre_scores_gemma":[0.9964605,0.0003084906,0.0005645735,0.0003083134,0.0001492146,0.00006049292,0.00004752732,0.00002867431,0.002072195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3450973,"threshold_uncertainty_score":0.582065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004063026521213674,"score_gpt":0.2099218176228959,"score_spread":0.2058587911016823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}