{"id":"W1985941121","doi":"10.1534/genetics.114.170217","title":"Understanding Rare Disease Pathogenesis: A Grand Challenge for Model Organisms","year":2014,"lang":"en","type":"letter","venue":"Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Canada's Michael Smith Genome Sciences Centre; Children's Hospital of Eastern Ontario; University of British Columbia","funders":"","keywords":"Biology; Genetics; Pathogenesis; Disease; Evolutionary biology; Immunology; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01204041,0.001077982,0.002345568,0.0007754657,0.003869082,0.00384649,0.003521301,0.03914599,0.004042137],"category_scores_gemma":[0.02737448,0.0008462048,0.001727876,0.0004539564,0.009024369,0.00797205,0.003833738,0.0773892,0.003809115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004751787,"about_ca_system_score_gemma":0.005359558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00413033,"about_ca_topic_score_gemma":0.00708635,"domain_scores_codex":[0.9923266,0.003001685,0.0006324877,0.0009421411,0.002610173,0.0004868436],"domain_scores_gemma":[0.9692909,0.02387945,0.000926419,0.0009160652,0.003061686,0.00192538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004737952,0.00005109582,0.0001947828,0.0001461932,0.00003175851,0.0007922013,0.0002149763,0.0001244173,0.0004512966,0.01740452,0.9599383,0.02060304],"study_design_scores_gemma":[0.0000956284,0.00008158317,0.0002160965,0.0003243717,0.00002958248,0.001344867,0.000392324,0.0003105493,0.0003708244,0.05053405,0.9462281,0.00007189329],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001041554,0.007752452,0.0005293284,0.9765528,0.01444672,0.000004874063,0.00002042048,0.00003843554,0.0005507781],"genre_scores_gemma":[0.001573408,0.007490748,0.0007957994,0.9563579,0.03190186,0.00003631891,0.00003299692,0.00003302903,0.001777914],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03914599,"threshold_uncertainty_score":0.06367654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.057943900059833,"score_gpt":0.2857735873205498,"score_spread":0.2278296872607168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}