{"id":"W1985952771","doi":"10.1074/jbc.275.9.6246","title":"Retroviral Transfection of Madin-Darby Canine Kidney Cells with Human MDR1 Results in a Major Increase in Globotriaosylceramide and 105- to 106-Fold Increased Cell Sensitivity to Verocytotoxin","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Globotriaosylceramide; Lactosylceramide; Molecular biology; Ceramide; Biology; Cell culture; Endoplasmic reticulum; Transfection; Biochemistry; Apoptosis; Glycolipid; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003953066,0.0005327784,0.0004179842,0.0002816445,0.0001995732,0.0006574475,0.0003188778,0.00049349,0.003024299],"category_scores_gemma":[0.0001556699,0.0003428897,0.000399732,0.000319636,0.0002939815,0.0003074586,0.0002890195,0.001286134,0.001153361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006596213,"about_ca_system_score_gemma":0.0001637213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006244096,"about_ca_topic_score_gemma":0.0008060951,"domain_scores_codex":[0.9995143,0.00006769374,0.00006140769,0.0001140186,0.0001524494,0.00009024365],"domain_scores_gemma":[0.9998022,0.00004672046,0.00004619778,0.0000396186,0.0000203435,0.0000449278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005875761,0.00003391823,0.00008664462,0.00002230189,0.000008620997,0.0000418411,0.00002550639,0.00003173486,0.9988757,0.0002462912,0.00007240983,0.0004963322],"study_design_scores_gemma":[0.00003787184,0.0002892697,0.00231569,0.000005835611,0.00002226067,0.0003399694,0.00002076641,0.001045166,0.9868195,0.00005725718,0.00903898,0.000007485045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799047,0.002639429,0.009370413,0.0003492368,0.0002389684,0.0001730389,0.002513214,0.0004288226,0.004382306],"genre_scores_gemma":[0.969119,0.001255649,0.01004563,0.0001755664,0.00006125221,0.000175131,0.007376096,0.00009483798,0.01169688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003024299,"threshold_uncertainty_score":0.01011735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390637276645462,"score_gpt":0.2483683057794941,"score_spread":0.2389776685028487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}