{"id":"W1986017121","doi":"10.4236/ojemd.2014.44009","title":"Gene Regulation of Catecholamine Biosynthetic Enzymes by Nitric Oxide in PC12 Cells","year":2014,"lang":"en","type":"article","venue":"Open Journal of Endocrine and Metabolic Diseases","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University","funders":"","keywords":"Tyrosine hydroxylase; Adrenal medulla; Sodium nitroprusside; Nitric oxide; Phenylethanolamine; Enzyme; Tyrosine 3-Monooxygenase; Protein kinase C; Chemistry; Dopamine; Catecholamine; Cholinergic; GTP cyclohydrolase I; Internal medicine; Endocrinology; Cell biology; Nitric oxide synthase; Biology; Biochemistry; Tetrahydrobiopterin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031031,0.0003497952,0.0006411732,0.0004611496,0.0005009314,0.0004545501,0.000333126,0.0003428745,0.001073438],"category_scores_gemma":[0.0002127325,0.0002070195,0.0006981695,0.0006612867,0.0004030725,0.0002365159,0.0002506973,0.0009301268,0.0005071508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005069794,"about_ca_system_score_gemma":0.0004420067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004624651,"about_ca_topic_score_gemma":0.008696281,"domain_scores_codex":[0.9995885,0.00003430905,0.00006058417,0.0001170475,0.0001161351,0.0000834415],"domain_scores_gemma":[0.9997858,0.00005590187,0.00003525542,0.0000344276,0.0000444442,0.00004409021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002790183,0.00007830626,0.0002833612,0.00008070833,0.00000747077,0.00008130341,0.00006131324,0.00008236918,0.9966522,0.0001203733,0.00009233783,0.002181339],"study_design_scores_gemma":[0.00003197999,0.0004560367,0.01079647,0.00001111126,0.00004309067,0.0002104768,0.00008930109,0.00109757,0.9823778,0.00006536212,0.004806765,0.00001396066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978385,0.006163465,0.008320947,0.0003566517,0.0002786207,0.00009350095,0.002398879,0.0002016284,0.003801461],"genre_scores_gemma":[0.9601606,0.005721614,0.01802814,0.0001739747,0.00007778018,0.000376131,0.00350752,0.00005169363,0.0119025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004624651,"threshold_uncertainty_score":0.009195507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191253033921223,"score_gpt":0.267132711788872,"score_spread":0.2552201814496597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}