{"id":"W1986021513","doi":"10.1016/s0301-472x(02)00810-x","title":"Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets","year":2002,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Canadian Blood Services","funders":"National Heart, Lung, and Blood Institute","keywords":"Thrombopoietin; Glycoprotein 130; Megakaryocyte; Cell biology; Biology; Oncostatin M; Signal transduction; Molecular biology; MAPK/ERK pathway; CD34; Protein kinase B; Haematopoiesis; Chemistry; Cytokine; Immunology; STAT3; Interleukin 6; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076329,0.0001780705,0.0001304714,0.0002760213,0.0002101032,0.0003073933,0.0001416724,0.0001968428,0.001611939],"category_scores_gemma":[0.0002004138,0.0002404358,0.0001745115,0.0001890922,0.0001757781,0.0001645001,0.0001657552,0.000424335,0.0003246159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379677,"about_ca_system_score_gemma":0.0001973665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007419898,"about_ca_topic_score_gemma":0.001014517,"domain_scores_codex":[0.999848,0.00002920989,0.00001017953,0.00001678156,0.00004611873,0.00004970252],"domain_scores_gemma":[0.9999328,0.00001826519,0.00001011316,0.0000137132,0.000006386164,0.00001863111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004858569,0.00005889477,0.0008444248,0.00002135999,0.000008176638,0.0001687654,0.00003259082,0.00007374488,0.9959925,0.0004258781,0.0001806739,0.001707252],"study_design_scores_gemma":[0.0001856656,0.000380352,0.05236004,0.000008301822,0.00003237737,0.002071449,0.00009214276,0.002293374,0.9383119,0.000580892,0.003676159,0.000007430734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979228,0.0005363815,0.0004816145,0.00007821304,0.00001077933,0.000009189319,0.0001632885,0.00001341847,0.0007843223],"genre_scores_gemma":[0.9969831,0.0005097999,0.0004081339,0.00004140207,0.000008283945,0.00002033109,0.0007084289,0.000006480593,0.001314008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611939,"threshold_uncertainty_score":0.005392492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006681096237895,"score_gpt":0.2727615348693504,"score_spread":0.2526947239069715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}