{"id":"W1986023178","doi":"10.1128/mcb.01701-13","title":"The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4<sup>+</sup> CD8<sup>+</sup> Thymocyte Survival","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Biology; Protein kinase A; Kinase; Cell biology; Extracellular; CD8; Thymocyte; Mitogen-activated protein kinase; Molecular biology; Signal transduction; Biochemistry; Antigen; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006662561,0.0003092858,0.0001396049,0.0001227835,0.000150417,0.0002630394,0.0001704183,0.0001888529,0.0008031761],"category_scores_gemma":[0.0001037053,0.00009775202,0.0001739563,0.00008321045,0.0001818698,0.0001639794,0.0002188557,0.0004066532,0.0005306686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016361,"about_ca_system_score_gemma":0.0001733619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002398231,"about_ca_topic_score_gemma":0.0002986524,"domain_scores_codex":[0.999923,0.00001014074,0.000005902395,0.00001391921,0.0000207817,0.00002624101],"domain_scores_gemma":[0.9999055,0.000009000692,0.0000367412,0.00001049616,0.00001168015,0.0000266914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005119576,0.000008857082,0.0002541782,0.00001783066,0.000002160048,0.00006255133,0.000003556532,0.00004712805,0.9983473,0.0001175281,0.00002960517,0.001058209],"study_design_scores_gemma":[0.00001305955,0.0001187436,0.01626773,0.000009124436,0.00001096029,0.001134288,0.00003644393,0.001539642,0.9765059,0.0003303385,0.004028703,0.000005040616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918939,0.00188023,0.003710872,0.0001011781,0.00002175695,0.00001100424,0.0002958594,0.0001237526,0.001961266],"genre_scores_gemma":[0.9967697,0.0005323782,0.001184036,0.00002167465,0.000006413854,0.00001073163,0.0002593335,0.00001465232,0.001201178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008031761,"threshold_uncertainty_score":0.002686858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008446801582782744,"score_gpt":0.2146456377138124,"score_spread":0.2061988361310296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}