{"id":"W1986042567","doi":"10.1016/j.bmcl.2009.03.132","title":"Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Methyltransferase; Stereochemistry; Substituent; Enzyme; Enzyme inhibitor; Alkylation; Biochemistry; Carboxylic acid; Methylation; Selectivity; DNA; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739396,0.0003441,0.0004522227,0.000185736,0.000189589,0.0003102829,0.0005200895,0.0003579504,0.002202158],"category_scores_gemma":[0.000217882,0.0001723251,0.0001504134,0.0002440473,0.0001859724,0.000279886,0.0003659588,0.0005436751,0.0004843052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833501,"about_ca_system_score_gemma":0.0002393703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009688613,"about_ca_topic_score_gemma":0.002426034,"domain_scores_codex":[0.9999014,0.00003072981,0.000008366937,0.00001558285,0.00001954081,0.000024394],"domain_scores_gemma":[0.9999404,0.00001436769,0.00001421327,0.000007831703,0.000008872198,0.00001444183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001654129,0.0001651402,0.0001766043,0.0003820577,0.00009004003,0.0003591444,0.0001104584,0.004684384,0.965519,0.002455518,0.0009700481,0.02343357],"study_design_scores_gemma":[0.0003194452,0.001811024,0.0004030092,0.00002217822,0.00007826556,0.0002618234,0.000042855,0.00313848,0.9790105,0.0003681625,0.01450976,0.00003446532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665115,0.0119965,0.01001126,0.0002669359,0.0001918733,0.0001341692,0.0005949851,0.0002776081,0.0100153],"genre_scores_gemma":[0.9893335,0.0039884,0.003050688,0.00007407326,0.00002358604,0.00005244482,0.0003167249,0.00002331803,0.003137408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002202158,"threshold_uncertainty_score":0.007366955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006268148701448749,"score_gpt":0.2338984643577967,"score_spread":0.2276303156563479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}