{"id":"W1986072777","doi":"10.1074/jbc.m010360200","title":"Nuclear Factor 1 Interferes with Sp1 Binding through a Composite Element on the Rat Poly(ADP-ribose) Polymerase Promoter to Modulate Its Activity in Vitro","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Promoter; Molecular biology; Biology; Poly ADP ribose polymerase; Transcription factor; Transcription (linguistics); Response element; Activator (genetics); RNA polymerase II; Polymerase; Gene expression; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625671,0.0005066451,0.0002746476,0.0002065571,0.0001301456,0.0002345194,0.0003286497,0.0002024554,0.001309589],"category_scores_gemma":[0.0001887364,0.0001338511,0.0002600121,0.0001432933,0.0003127136,0.0001235487,0.0002184677,0.0008093613,0.0003000314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493017,"about_ca_system_score_gemma":0.0002468393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004595111,"about_ca_topic_score_gemma":0.0007232888,"domain_scores_codex":[0.9996684,0.0000861513,0.00002303971,0.0000745276,0.00006797487,0.00008005228],"domain_scores_gemma":[0.9998437,0.00004336705,0.00003712601,0.00002010897,0.0000154295,0.00004034451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001710255,0.00005966447,0.00008316131,0.00002329073,0.000004423883,0.00001353197,0.000009591559,0.00006398579,0.998549,0.00006200556,0.00002240901,0.0009379322],"study_design_scores_gemma":[0.00002693057,0.0007702864,0.0009492442,0.000006382154,0.00001489082,0.00009673592,0.00001316057,0.001087331,0.9958969,0.00003453277,0.001100507,0.000003180463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990199,0.002453717,0.005768149,0.00009731975,0.00006436664,0.00003239361,0.0001130271,0.00008384239,0.001188331],"genre_scores_gemma":[0.9927227,0.0009759575,0.003798862,0.00004905642,0.00002386509,0.00005674635,0.0003954579,0.00001826033,0.00195909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309589,"threshold_uncertainty_score":0.004381061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05592043442531127,"score_gpt":0.3116253351554585,"score_spread":0.2557049007301472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}