{"id":"W1986072799","doi":"10.1523/jneurosci.0968-09.2009","title":"BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"BMI1; Biology; Cancer research; Cancer stem cell; Stem cell; Gene knockdown; Oncogene; Clonogenic assay; Small hairpin RNA; Cell biology; Cell; Cell cycle; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659418,0.00009282387,0.000103508,0.0000794947,0.0001193672,0.00004611989,0.000280372,0.0000587506,0.000001530947],"category_scores_gemma":[0.00004254339,0.00007888362,0.0000886862,0.0001349658,0.00005458496,0.00001065474,0.0000357854,0.00009994586,9.403532e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001334538,"about_ca_system_score_gemma":0.00007457555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001128192,"about_ca_topic_score_gemma":0.000003248487,"domain_scores_codex":[0.9990664,0.00004225288,0.0002904752,0.0001645278,0.0002436319,0.000192722],"domain_scores_gemma":[0.9992852,0.000006233994,0.0002723492,0.0001683292,0.0001500748,0.0001178628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000272328,0.00006603702,0.0006163564,0.000002577869,6.900987e-7,0.00001666737,0.00002923659,0.0003023174,0.9971582,0.00002305288,0.00009272062,0.001664915],"study_design_scores_gemma":[0.0004043563,0.002754549,0.01950255,0.000006993107,0.000007152887,0.00003559568,0.00003830227,0.00009714659,0.9689808,0.0002143152,0.007848429,0.0001097622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971422,0.0002912698,0.001486101,0.000153429,0.00022664,0.00004841902,0.000001632739,0.000003056798,0.0006472321],"genre_scores_gemma":[0.9985992,0.0001162205,0.0002527435,0.000239286,0.0001919854,2.480032e-7,5.430566e-7,0.000006299538,0.0005934229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02817734,"threshold_uncertainty_score":0.321678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431336662138595,"score_gpt":0.2782688614066716,"score_spread":0.2639554947852856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}