{"id":"W1986072799","doi":"10.1523/jneurosci.0968-09.2009","title":"BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"BMI1; Biology; Cancer research; Cancer stem cell; Stem cell; Gene knockdown; Oncogene; Clonogenic assay; Small hairpin RNA; Cell biology; Cell; Cell cycle; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133218,0.0001229899,0.0001768857,0.0002135709,0.0001234575,0.0001833993,0.00009950138,0.0001125586,0.0008000489],"category_scores_gemma":[0.0001192148,0.00006313057,0.0001251803,0.0001332837,0.00008802641,0.00008766402,0.0001967471,0.0002805954,0.0004014029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002750066,"about_ca_system_score_gemma":0.000312198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001835953,"about_ca_topic_score_gemma":0.003033063,"domain_scores_codex":[0.9999499,0.000005097149,0.00000408476,0.000007469245,0.00001856702,0.0000148508],"domain_scores_gemma":[0.9999623,0.000004823155,0.000006247082,0.000006708189,0.000007774241,0.00001219281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002032254,0.0000477854,0.0004298464,0.00005178925,0.000007059238,0.00002955637,0.00002671008,0.0001449586,0.990218,0.0001924373,0.0002587019,0.008389947],"study_design_scores_gemma":[0.00005265431,0.0006358231,0.007921222,0.00001043121,0.00002547235,0.0001571735,0.00003079828,0.001465751,0.9773982,0.0001194816,0.01217592,0.000007003856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917995,0.00355787,0.001445761,0.0001351906,0.00003399097,0.00004330181,0.000924462,0.0001294307,0.001930575],"genre_scores_gemma":[0.993169,0.001267068,0.0009122007,0.00006705801,0.000009389937,0.00003479488,0.001815747,0.00002811891,0.002696696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835953,"threshold_uncertainty_score":0.003650486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431336662138595,"score_gpt":0.2782688614066716,"score_spread":0.2639554947852856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}