{"id":"W1986077790","doi":"10.1021/jm0101186","title":"[2‘,6‘-Dimethyltyrosine]Dynorphin A(1−11)-NH<sub>2</sub>Analogues Lacking an N-Terminal Amino Group:  Potent and Selective κ Opioid Antagonists","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Dynorphin; Agonist; Stereochemistry; Dynorphin A; Antagonist; κ-opioid receptor; Dermorphin; Enkephalin; δ-opioid receptor; Propanoic acid; Opioid peptide; Receptor; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003546064,0.0003072359,0.0005111259,0.00009290253,0.0002168861,0.00007125131,0.0003993634,0.0001263685,0.00002300821],"category_scores_gemma":[0.0003485257,0.0002482099,0.0001336329,0.0002532987,0.0004026291,0.0003562507,0.0001096821,0.0007644879,0.000004929533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008029086,"about_ca_system_score_gemma":0.00008873079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001551636,"about_ca_topic_score_gemma":0.000004833275,"domain_scores_codex":[0.9977704,0.0001258547,0.0006152262,0.0004588208,0.0005642963,0.0004654136],"domain_scores_gemma":[0.9984558,0.0001991758,0.0005903481,0.0001929241,0.0001500402,0.0004116741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000386318,0.0001935293,0.001472214,0.00007404298,0.00001289768,0.002741649,0.0001343125,0.000008596638,0.9879394,0.00002089241,0.0002834349,0.0067327],"study_design_scores_gemma":[0.0009943431,0.001134439,0.01487252,0.0001927336,0.00007409873,0.0161203,0.0001955137,0.0001217999,0.9643896,0.0004727344,0.0011715,0.0002604297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998782,0.0003090353,0.0000497097,0.0001988388,0.0002106185,0.00007045149,0.000007845517,0.0000271419,0.0003443122],"genre_scores_gemma":[0.9968964,0.0008571099,0.0001069558,0.0007624078,0.001292094,0.000001819767,0.000004155541,0.00003255785,0.00004647538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02354983,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131319352258929,"score_gpt":0.2636696213705322,"score_spread":0.242356427847943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}