{"id":"W1986077790","doi":"10.1021/jm0101186","title":"[2‘,6‘-Dimethyltyrosine]Dynorphin A(1−11)-NH<sub>2</sub>Analogues Lacking an N-Terminal Amino Group:  Potent and Selective κ Opioid Antagonists","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Dynorphin; Agonist; Stereochemistry; Dynorphin A; Antagonist; κ-opioid receptor; Dermorphin; Enkephalin; δ-opioid receptor; Propanoic acid; Opioid peptide; Receptor; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246162,0.0002454144,0.0002181622,0.00009176652,0.000103093,0.0001599661,0.0002499374,0.0001814902,0.0009186495],"category_scores_gemma":[0.0001015154,0.0001445227,0.0001091022,0.00006966386,0.0001540324,0.0001452422,0.000124101,0.0005067021,0.0003026218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045133,"about_ca_system_score_gemma":0.0001265985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121896,"about_ca_topic_score_gemma":0.001024149,"domain_scores_codex":[0.9998987,0.00002003756,0.00001109396,0.00001918979,0.00002134746,0.0000296707],"domain_scores_gemma":[0.9999272,0.00001136961,0.00002445337,0.000004714596,0.000007454444,0.0000248216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001456673,0.00003359934,0.00006371956,0.00002879951,0.000005616513,0.00004066191,0.00001040141,0.0001143845,0.9984547,0.00006753871,0.00002797137,0.001006955],"study_design_scores_gemma":[0.0001499785,0.002978014,0.003628477,0.000007700676,0.00002536801,0.0005438888,0.00003620923,0.001148585,0.985479,0.00003827584,0.005944309,0.00002013526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962445,0.0009712063,0.0009294546,0.00003612035,0.00002433962,0.00003851597,0.0001132167,0.00001781054,0.001624723],"genre_scores_gemma":[0.993665,0.001018126,0.002694251,0.00007117769,0.0000187516,0.00005252971,0.0003011975,0.000009926792,0.00216919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009186495,"threshold_uncertainty_score":0.003073215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131319352258929,"score_gpt":0.2636696213705322,"score_spread":0.242356427847943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}