{"id":"W1986080343","doi":"10.2164/jandrol.111.013870","title":"Specialized Distribution of the Histone Methyltransferase Ezh2 in the Nuclear Apical Region of Round Spermatids and Its Interaction With the Histone Variant H1t2","year":2012,"lang":"en","type":"article","venue":"Journal of Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital; McGill University","funders":"","keywords":"Spermiogenesis; EZH2; Spermatid; Chromatin; Histone methyltransferase; Biology; Cell biology; Histone; Chromatin immunoprecipitation; Histone H3; Epigenetics; Chromatin remodeling; Histone H2A; Histone methylation; Sperm; Molecular biology; Genetics; Gene expression; Nucleus; DNA methylation; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006565031,0.0001366247,0.0001079229,0.0001341547,0.00009937242,0.0002056959,0.0001142247,0.0001568188,0.0009486525],"category_scores_gemma":[0.00007545875,0.0001191217,0.00009767544,0.00007526493,0.0001673099,0.0001535989,0.0001718794,0.0001910471,0.0002139291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567456,"about_ca_system_score_gemma":0.0001002893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005131451,"about_ca_topic_score_gemma":0.001284301,"domain_scores_codex":[0.9999208,0.000009307223,0.000003360486,0.00002911645,0.00001893453,0.00001848239],"domain_scores_gemma":[0.9999322,0.000006919892,0.00002583321,0.000006379124,0.000006749801,0.00002191328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003568784,0.000001512199,0.0008355305,0.000007032393,0.000002977601,0.0000439855,0.000008156164,0.0000147595,0.9985583,0.00006022406,0.000006189126,0.000425565],"study_design_scores_gemma":[0.0000130716,0.0001085396,0.1001625,0.00000330472,0.00002492482,0.0007746376,0.0000637997,0.0009305519,0.8959749,0.0001059671,0.001830168,0.000007707762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951067,0.0009237722,0.0032857,0.00003478843,0.000005104119,0.000003917677,0.0001060474,0.00002483997,0.0005090991],"genre_scores_gemma":[0.997902,0.0002225411,0.0008328432,0.00001532815,0.00000376555,0.000004119776,0.000108357,0.000007483892,0.0009034666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009486525,"threshold_uncertainty_score":0.00317353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527622807508716,"score_gpt":0.2780831246679529,"score_spread":0.2628068965928657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}