{"id":"W1986080343","doi":"10.2164/jandrol.111.013870","title":"Specialized Distribution of the Histone Methyltransferase Ezh2 in the Nuclear Apical Region of Round Spermatids and Its Interaction With the Histone Variant H1t2","year":2012,"lang":"en","type":"article","venue":"Journal of Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital; McGill University","funders":"","keywords":"Spermiogenesis; EZH2; Spermatid; Chromatin; Histone methyltransferase; Biology; Cell biology; Histone; Chromatin immunoprecipitation; Histone H3; Epigenetics; Chromatin remodeling; Histone H2A; Histone methylation; Sperm; Molecular biology; Genetics; Gene expression; Nucleus; DNA methylation; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006285491,0.00007339382,0.0001662228,0.00002797606,0.00005049937,0.000005503427,0.0001279429,0.00009573331,0.000006834445],"category_scores_gemma":[0.0000734007,0.00003568045,0.00006685768,0.00007620194,0.0001358984,0.00001221311,0.00002176806,0.0001683777,1.604965e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002032995,"about_ca_system_score_gemma":0.00002900168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001978642,"about_ca_topic_score_gemma":0.00003043165,"domain_scores_codex":[0.9990602,0.0003435214,0.000302313,0.00006539312,0.0001255486,0.0001030674],"domain_scores_gemma":[0.9993792,0.00005579078,0.0003071803,0.0001324357,0.00009892187,0.00002648902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002382516,0.0004317608,0.005589957,0.00004409425,0.0001366201,0.00001142663,0.002651698,0.0001944017,0.9829167,0.0030988,0.0004607576,0.002081227],"study_design_scores_gemma":[0.0069076,0.005961793,0.38325,0.0001315491,0.0006908663,0.003013182,0.001557188,0.0004694266,0.4912654,0.001054352,0.1052865,0.0004121043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931903,0.00233426,0.00214417,0.001938722,0.000164765,0.000104059,0.000004172027,4.611928e-7,0.0001190963],"genre_scores_gemma":[0.9990024,0.0006567497,0.00005091691,0.00009317576,0.0001708074,0.000001020619,0.000005723452,0.0000054835,0.00001369762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4916513,"threshold_uncertainty_score":0.1455006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527622807508716,"score_gpt":0.2780831246679529,"score_spread":0.2628068965928657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}