{"id":"W1986093701","doi":"10.1038/sj.leu.2402455","title":"Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia","year":2002,"lang":"en","type":"article","venue":"Leukemia","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pediatric Oncology Group","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Mitoxantrone; Etoposide; Pharmacokinetics; Pharmacology; Medicine; Myeloid leukemia; Cytarabine; Toxicity; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004781902,0.0002100286,0.0003898985,0.0001632285,0.00003815939,0.000007827942,0.00007490413,0.00005762791,0.0001973558],"category_scores_gemma":[0.00000235152,0.0001453061,0.00003970501,0.0003102028,0.0001240119,0.0001041852,0.00001293277,0.0003324343,0.000007783497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453219,"about_ca_system_score_gemma":0.0001052582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140583,"about_ca_topic_score_gemma":0.0002688508,"domain_scores_codex":[0.9989204,0.00001230149,0.0002674997,0.0002918673,0.0002378176,0.0002700448],"domain_scores_gemma":[0.999476,0.00001697894,0.00009807,0.0002319593,0.00004554035,0.0001314951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00328841,0.0004921616,0.783259,0.0003296864,0.00158467,0.001231929,0.001693896,0.0006005455,0.191481,0.0004760218,0.0007917294,0.0147709],"study_design_scores_gemma":[0.01347296,0.0008762596,0.8864865,0.000744631,0.001051238,0.001709235,0.0001672535,0.001146795,0.09237619,0.00004555081,0.001480477,0.0004429485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958159,0.0003919107,0.0002513538,0.0003227399,0.00004511906,0.000420421,0.00001353977,0.00004700313,0.002692048],"genre_scores_gemma":[0.9936724,0.000591708,0.00261167,0.0001405536,0.00008615169,0.00002510846,0.00003105964,0.00003601778,0.00280528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032274,"threshold_uncertainty_score":0.5925412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006500770798625346,"score_gpt":0.2255509247561506,"score_spread":0.2190501539575252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}