{"id":"W1986095517","doi":"10.6000/1927-7229.2014.03.03.2","title":"Acetylation of 1,2,5,8-tetrahydroxy-9,10-anthraquinone Improves Binding to DNA and Shows Enhanced Superoxide Formation that Explains Better Cytotoxicity on JURKAT T Lymphocyte Cells","year":2014,"lang":"en","type":"article","venue":"Journal of Analytical Oncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Binding constant; Anthraquinones; Chemistry; Superoxide; DNA; Jurkat cells; Anthraquinone; Stereochemistry; Cytotoxicity; Binding site; Acetylation; Singlet oxygen; Biochemistry; Enzyme; In vitro; Organic chemistry; Biology; Oxygen; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008943608,0.0001853722,0.0007997286,0.0003931378,0.00007036661,0.00002256182,0.00009144117,0.0002813194,0.00007604458],"category_scores_gemma":[0.0002934624,0.0001504465,0.0002356024,0.0002031352,0.0001213768,0.000347296,0.00002895694,0.0002932243,0.00001255581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004976434,"about_ca_system_score_gemma":0.0001244012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003836449,"about_ca_topic_score_gemma":0.000009857564,"domain_scores_codex":[0.9982264,0.0001457648,0.0007249335,0.0001959095,0.000444024,0.0002629858],"domain_scores_gemma":[0.9984323,0.0004531471,0.0004415838,0.0001750523,0.0002157419,0.0002821503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001031382,0.0001785972,0.00008236283,0.00006908656,0.0001162156,0.00001060726,0.0006336956,0.00005617151,0.9715713,0.00008213151,0.0002823521,0.02588605],"study_design_scores_gemma":[0.003187584,0.004307178,0.001829981,0.0001826554,0.0002083298,0.0001386908,0.0003340855,0.002452811,0.9859389,0.00009471507,0.001193837,0.0001312316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846706,0.00001623092,0.01086247,0.002128954,0.0001707629,0.0002708246,0.00000404505,0.00001122856,0.001864912],"genre_scores_gemma":[0.996271,0.0000677662,0.001674675,0.001435027,0.0004102651,0.000003430759,0.000005907267,0.0000179325,0.0001139539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02575482,"threshold_uncertainty_score":0.6135029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432688240202732,"score_gpt":0.2952691526115001,"score_spread":0.2709422702094728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}