{"id":"W1986109787","doi":"10.1186/1471-2091-14-6","title":"The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand","year":2013,"lang":"en","type":"article","venue":"BMC Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; McMaster University","funders":"Centre for Blood Research, University of British Columbia; International Society on Thrombosis and Haemostasis; McMaster University; Oklahoma Medical Research Foundation; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Thrombin; Heparin cofactor II; Chemistry; Serpin; Hirudin; Biochemistry; Biotinylation; Antithrombin; Discovery and development of direct thrombin inhibitors; Protease; Heparin; Enzyme; Biology; Platelet; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002310889,0.0002240011,0.0002241726,0.00001332109,0.0002615276,0.0000369059,0.0002814954,0.0002472007,0.00002179264],"category_scores_gemma":[0.0001484705,0.0001740137,0.0002000061,0.00005144789,0.0001570336,0.000007444924,0.0002363353,0.00007823115,0.00001302636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000187613,"about_ca_system_score_gemma":0.0001197473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004125341,"about_ca_topic_score_gemma":0.000002172682,"domain_scores_codex":[0.9987537,0.00004517303,0.0002724447,0.0004525224,0.0001593022,0.0003169059],"domain_scores_gemma":[0.9988928,0.00005295798,0.000165991,0.0005790949,0.0002082365,0.0001009496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747271,0.00007739303,0.0001660096,0.0001771552,0.00004192907,0.00000100533,0.00001488024,3.752454e-7,0.9964043,0.00004961397,0.00234863,0.0003439095],"study_design_scores_gemma":[0.0009262338,0.0005751608,0.0005893629,0.00008896185,0.00002867129,0.0000506547,0.00003823235,0.000103633,0.9949399,0.0007293994,0.00170447,0.0002253095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970034,0.0006909383,0.001121759,0.00006740718,0.0001242898,0.0006888389,0.00008865648,0.00001341846,0.0002012901],"genre_scores_gemma":[0.9976056,0.00004130174,0.0007627364,0.0001112794,0.0002007794,0.0002397015,0.000134685,0.00002846123,0.0008754823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464462,"threshold_uncertainty_score":0.7096072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874645669857302,"score_gpt":0.2605935440635416,"score_spread":0.2418470873649685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}