{"id":"W1986125636","doi":"10.2174/092986709788682218","title":"1,5-Diaryl-3-oxo-1,4-pentadienes: A Case for Antineoplastics with Multiple Targets","year":2009,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Stereochemistry; Enzyme; Molecule; Combinatorial chemistry; Molecular model; In vitro; In vivo; Cytotoxicity; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002303773,0.0010054,0.00234101,0.00003912243,0.0001954033,0.00004610741,0.0005123886,0.000650783,0.0006252383],"category_scores_gemma":[0.0009686204,0.0006210551,0.000673,0.00016975,0.0002417255,0.00004941051,0.0001015712,0.0009830681,0.00001392093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721388,"about_ca_system_score_gemma":0.0003220534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005879745,"about_ca_topic_score_gemma":0.000003307575,"domain_scores_codex":[0.9969246,0.00002938468,0.0008096859,0.001077521,0.0003883872,0.0007704261],"domain_scores_gemma":[0.996612,0.001484709,0.0007239848,0.00060245,0.0001377974,0.0004390481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007022572,0.0004722307,0.00003113964,0.05377761,0.0001518654,0.0007596532,0.00001037698,1.721032e-7,0.0002090983,0.000001198229,0.0009221446,0.9435943],"study_design_scores_gemma":[0.0007145498,0.00007360228,5.823346e-7,0.01974518,0.001497439,0.004860717,0.00004141933,0.00004102682,0.002101286,0.000008931299,0.9700754,0.0008398435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007017094,0.996335,0.0001629138,0.00001339583,0.0002232413,0.0003926874,0.0007844793,0.0001445297,0.001242058],"genre_scores_gemma":[0.002102024,0.9933881,0.0002710968,0.00001205462,0.002327682,0.0003013453,0.001252442,0.00007515211,0.0002701534],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9691533,"threshold_uncertainty_score":0.9996241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06709664724713132,"score_gpt":0.333431550305903,"score_spread":0.2663349030587717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}