{"id":"W1986125636","doi":"10.2174/092986709788682218","title":"1,5-Diaryl-3-oxo-1,4-pentadienes: A Case for Antineoplastics with Multiple Targets","year":2009,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Stereochemistry; Enzyme; Molecule; Combinatorial chemistry; Molecular model; In vitro; In vivo; Cytotoxicity; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008322409,0.0003559646,0.0009329528,0.0005836923,0.0003058524,0.001420249,0.0007653083,0.001790094,0.001817729],"category_scores_gemma":[0.000636796,0.0002236474,0.0003119772,0.0006917366,0.001462562,0.003457954,0.0007598375,0.002807136,0.00121318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007249874,"about_ca_system_score_gemma":0.000473457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002301215,"about_ca_topic_score_gemma":0.0006609096,"domain_scores_codex":[0.9997351,0.00007987917,0.00002689226,0.00005640487,0.00006242658,0.00003922964],"domain_scores_gemma":[0.999725,0.0001378985,0.00003449143,0.00001967304,0.00004857303,0.00003426469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003579454,0.0001744196,0.0006062762,0.01128528,0.0001089884,0.01013064,0.001612411,0.001731634,0.08460419,0.3243801,0.0358198,0.5291883],"study_design_scores_gemma":[0.00001781324,0.0002059782,0.0002538395,0.0005925596,0.00003845672,0.008109137,0.0003088542,0.0002923102,0.005000416,0.02372102,0.961436,0.0000235222],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005189485,0.9658129,0.006984025,0.006895063,0.002062188,0.00002708496,0.00002706074,0.00005416855,0.01294812],"genre_scores_gemma":[0.03762093,0.9209156,0.01041637,0.008720928,0.002053353,0.00007049627,0.00005936584,0.0000408856,0.02010215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001817729,"threshold_uncertainty_score":0.006080925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06709664724713132,"score_gpt":0.333431550305903,"score_spread":0.2663349030587717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}