{"id":"W1986138054","doi":"10.1016/j.bcp.2007.04.009","title":"Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor","year":2007,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Muscarinic acetylcholine receptor; Cooperativity; Chemistry; Receptor; Membrane; Cholesterol; Cooperative binding; Sf9; Sarcolemma; Biophysics; Binding site; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007291955,0.0001624096,0.0002032658,0.000051475,0.00003788477,0.000007567341,0.0003500517,0.0002370335,0.0002336108],"category_scores_gemma":[0.00005477111,0.0001207507,0.0001005452,0.0001515743,0.0001331618,0.000003419986,0.0001052208,0.00020387,0.00001333503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000162594,"about_ca_system_score_gemma":0.0000539138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002961194,"about_ca_topic_score_gemma":0.000005664753,"domain_scores_codex":[0.998726,0.0001250995,0.0003578137,0.0003272973,0.0001293058,0.0003345362],"domain_scores_gemma":[0.9994991,0.00005685692,0.0001025754,0.0002038573,0.00006120228,0.00007642405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000184378,0.0001822912,0.0002525399,0.00001118634,0.00001885186,0.000004995686,0.0001031624,0.000007227327,0.9936486,0.00003189236,0.004741185,0.0008137054],"study_design_scores_gemma":[0.0009209316,0.0003054072,0.0007146141,0.000007876954,0.0000166866,0.000026899,0.00008412966,0.00002974507,0.9885314,0.00001472526,0.009209408,0.0001381627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979639,0.0005135934,0.0004422115,0.0001292074,0.0003197301,0.0002596534,0.000006892904,0.000006228014,0.0003585572],"genre_scores_gemma":[0.9979122,0.0001213448,0.0002243011,0.001202277,0.0003719735,0.00002817512,0.00003813292,0.00001506725,0.00008655362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005117171,"threshold_uncertainty_score":0.492407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131506001306189,"score_gpt":0.3102097673524323,"score_spread":0.2988947073393705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}