{"id":"W1986141266","doi":"10.1016/j.dci.2009.12.018","title":"Co-stimulation with TLR7/8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells","year":2010,"lang":"en","type":"article","venue":"Developmental & Comparative Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"TLR9; TLR7; Agonist; Biology; Innate immune system; TLR3; Stimulation; Immune system; Peripheral blood mononuclear cell; CpG Oligodeoxynucleotide; Receptor; Immunology; TLR4; Toll-like receptor; Endocrinology; Gene expression; In vitro; DNA methylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003303098,0.0004322928,0.0006108799,0.0002846324,0.0002809316,0.0005557728,0.0002297046,0.0004401424,0.004828498],"category_scores_gemma":[0.0002599199,0.0002176052,0.0004676362,0.0001856122,0.0002599623,0.0001975842,0.0005059955,0.001347551,0.002118491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702403,"about_ca_system_score_gemma":0.0002260161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003159317,"about_ca_topic_score_gemma":0.0007095024,"domain_scores_codex":[0.9994138,0.0001589895,0.00006807964,0.0000735635,0.0001056154,0.0001800653],"domain_scores_gemma":[0.9996746,0.0001125327,0.00003919548,0.00004962282,0.00003793355,0.00008616679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005179927,0.00007137672,0.0002559633,0.00005433629,0.000008593471,0.0001182284,0.00002740161,0.00002136873,0.9977795,0.00003351791,0.00009365362,0.00101804],"study_design_scores_gemma":[0.00009890343,0.001003573,0.01681824,0.00002949805,0.00005722591,0.0007547709,0.0001903972,0.0006013847,0.974736,0.00009081638,0.005607463,0.00001178638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925328,0.00232613,0.001129879,0.0001866678,0.0002071346,0.00004645638,0.000424075,0.00004701784,0.003099866],"genre_scores_gemma":[0.9907489,0.0009730895,0.001421696,0.0002436488,0.000144922,0.000110515,0.001204394,0.0000253715,0.005127401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004828498,"threshold_uncertainty_score":0.01615286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259822582355592,"score_gpt":0.2509423307871513,"score_spread":0.2383441049635954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}