{"id":"W1986198423","doi":"10.1042/bj20030609","title":"Variations in aggrecan structure modulate its susceptibility to aggrecanases","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Aggrecan; Aggrecanase; Cleave; Chemistry; Proteoglycan; Proteolysis; Cell biology; Biochemistry; Immunoglobulin D; Cartilage; Cleavage (geology); Biology; Anatomy; Immunology; Enzyme; Extracellular matrix; Osteoarthritis; Medicine; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814387,0.0002485306,0.0001898656,0.0001969002,0.00009258811,0.0003235188,0.000100044,0.0002877728,0.001055138],"category_scores_gemma":[0.0003789954,0.0001912998,0.0002388223,0.0001300326,0.0001681636,0.0001521268,0.0001562025,0.0002876099,0.0004033968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001657243,"about_ca_system_score_gemma":0.00008228997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000412314,"about_ca_topic_score_gemma":0.000367521,"domain_scores_codex":[0.9998247,0.00004255792,0.0000181082,0.00003379414,0.00003052974,0.00005039948],"domain_scores_gemma":[0.9997854,0.0000531668,0.00005483279,0.00002861222,0.00003175343,0.00004633365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126386,0.000007985927,0.0005662481,0.00001220493,0.000006948278,0.00003930203,0.00001698747,0.00003122323,0.9988273,0.00001286371,0.000006894075,0.00035954],"study_design_scores_gemma":[0.00001967673,0.0005831572,0.05089106,0.000007800983,0.00003918466,0.001022846,0.00007665606,0.0004287978,0.9460059,0.00006759598,0.0008476399,0.000009830906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989221,0.0005100236,0.000220751,0.00001332494,0.000002640618,0.000004822781,0.00005097082,0.000005333101,0.0002701172],"genre_scores_gemma":[0.9989575,0.0002409346,0.0001870039,0.00001632807,0.000003237727,0.000006255749,0.00015449,0.000005820643,0.0004283579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055138,"threshold_uncertainty_score":0.003529847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489527081181924,"score_gpt":0.2857313863362864,"score_spread":0.2708361155244671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}