{"id":"W1986213329","doi":"10.1186/1471-2261-13-2","title":"Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart","year":2013,"lang":"en","type":"article","venue":"BMC Cardiovascular Disorders","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Investigaciones Científicas y Técnicas; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Ventricle; Muscle hypertrophy; Brain natriuretic peptide; Heart failure; Endocrinology; Atrial natriuretic peptide; Medicine; Bicarbonate; Hypertrophic cardiomyopathy; Cardiology; Carbonic anhydrase II; Carbonic anhydrase; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858889,0.00007417744,0.0001638115,0.00006514434,0.00002759391,0.000005542369,0.00004185566,0.00007933759,0.000008898511],"category_scores_gemma":[0.00004008569,0.00007748154,0.0001937065,0.00009601322,0.00005541715,0.000008115892,0.00003178398,0.00003857017,0.000001283158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006272453,"about_ca_system_score_gemma":0.0000180599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002475698,"about_ca_topic_score_gemma":0.000070845,"domain_scores_codex":[0.999286,0.0000848114,0.0001967405,0.000213115,0.0001202912,0.00009905213],"domain_scores_gemma":[0.9995634,0.000005336015,0.00005130233,0.000303528,0.00004782136,0.00002860139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001013966,0.00004610343,0.03024343,0.00004373986,0.0000284927,7.611988e-8,0.00001917137,0.001961977,0.9670157,0.000006578684,0.00004361271,0.0005809083],"study_design_scores_gemma":[0.001010133,0.0001023824,0.09158136,0.0000312282,0.00003007792,0.000003377859,0.0002283045,0.0003135449,0.9058502,0.00005068625,0.000676904,0.0001218197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903563,0.00624399,0.003069702,0.00001370956,0.00003535308,0.0002154018,0.000002268356,0.000004699994,0.00005860971],"genre_scores_gemma":[0.9990303,0.000388513,0.0004443595,0.000009338474,0.0000242913,0.00002591704,0.00005329417,0.00001083905,0.00001317569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06133793,"threshold_uncertainty_score":0.3159606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003065255056508,"score_gpt":0.2161033646295071,"score_spread":0.206072712078942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}