{"id":"W1986231469","doi":"10.1016/j.alcohol.2011.04.001","title":"Ethanol causes endoplasmic reticulum stress and impairment of insulin secretion in pancreatic β-cells","year":2011,"lang":"en","type":"article","venue":"Alcohol","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Research Manitoba; Manitoba Health Research Council","keywords":"Internal medicine; Endocrinology; Endoplasmic reticulum; Insulin; Tolbutamide; Diazoxide; Unfolded protein response; Insulin receptor; Insulin oscillation; Protein kinase C; Biology; Chemistry; Insulin resistance; Signal transduction; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284104,0.0001123295,0.0002863373,0.0001322867,0.00001465738,0.000003744949,0.00003139961,0.00007604939,0.0003090673],"category_scores_gemma":[0.00009073695,0.00009392108,0.00003738871,0.0001294784,0.00008174495,0.00004832285,0.00002340877,0.00009394532,0.00002409795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002396806,"about_ca_system_score_gemma":0.00004170562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003861829,"about_ca_topic_score_gemma":0.00002162573,"domain_scores_codex":[0.9992067,0.00004808011,0.000263107,0.0001756842,0.0001392019,0.0001672589],"domain_scores_gemma":[0.9995173,0.00007979704,0.00008003655,0.0001889701,0.0000420165,0.00009189612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002977989,0.000488918,0.8467768,0.0004035918,0.00008645767,0.00003945321,0.00196949,0.000001965892,0.1491054,0.0001626708,0.000135233,0.0005321895],"study_design_scores_gemma":[0.002710049,0.000540986,0.3245325,0.0004022974,0.000127667,0.00001151442,0.0005761248,0.0002549822,0.6705874,0.0001106108,0.00004819637,0.00009767185],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948099,0.0003783119,0.00001135795,0.00005044266,0.00008913162,0.0003638523,0.000011711,0.00002785373,0.004257464],"genre_scores_gemma":[0.9987665,0.0003035667,0.0004778262,0.0001359345,0.00002551949,0.00003199157,0.00001330596,0.00001175836,0.0002336026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5222443,"threshold_uncertainty_score":0.382999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02617925735791983,"score_gpt":0.2514091788806911,"score_spread":0.2252299215227712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}