{"id":"W1986248946","doi":"10.6000/1927-7229.2014.03.03.5","title":"PGE2 Upregulates IL-8 Via P38MAPK-Dependent Dual-Activation of CHOP and C/EBP-β in Human Astrocytomas","year":2014,"lang":"en","type":"article","venue":"Journal of Analytical Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chromatin immunoprecipitation; Signal transduction; Transcription factor; Downregulation and upregulation; Molecular biology; Ccaat-enhancer-binding proteins; Electrophoretic mobility shift assay; Cancer research; Biology; Transfection; CHOP; Transcription (linguistics); Phosphorylation; Chemistry; Cell biology; Promoter; Gene expression; Gene; Nuclear protein; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007424413,0.0002850178,0.0001766572,0.0002132811,0.0001392612,0.0001814799,0.00007087151,0.0001275948,0.0009325133],"category_scores_gemma":[0.00005295087,0.0001092476,0.000232556,0.0001533013,0.0001459376,0.0001076269,0.0001498397,0.0003217747,0.0003344048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001363797,"about_ca_system_score_gemma":0.0001346678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005932086,"about_ca_topic_score_gemma":0.0008833308,"domain_scores_codex":[0.9999317,0.00001089056,0.000007339285,0.00001162527,0.0000189621,0.00001941534],"domain_scores_gemma":[0.9999716,0.000004172428,0.000006664267,0.000004841449,0.000005016129,0.00000769388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280082,0.00003636287,0.000220469,0.00003117878,0.000003601463,0.00006766968,0.00001512786,0.00002174341,0.9989208,0.0000298585,0.00001893953,0.0005062341],"study_design_scores_gemma":[0.00003728109,0.0003748856,0.007616317,0.000003422399,0.00001964952,0.0003528575,0.0000413487,0.0005469908,0.9891344,0.00004824399,0.001821892,0.000002699959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996585,0.000840731,0.001389174,0.00006079731,0.00002195851,0.00002722555,0.0002171301,0.00004064057,0.000817226],"genre_scores_gemma":[0.9944198,0.000852318,0.001848478,0.00003569005,0.000009532321,0.00005323973,0.0004279667,0.000006872156,0.002346228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009325133,"threshold_uncertainty_score":0.003119588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142169092525353,"score_gpt":0.2901349130478172,"score_spread":0.2759180037952819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}