{"id":"W1986250787","doi":"10.2133/dmpk.21.492","title":"Temporal Decline in Sirolimus Elimination Immediately After Pancreatic Islet Transplantation","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sirolimus; Medicine; Tacrolimus; Pharmacokinetics; Transplantation; Pharmacology; Islet; NONMEM; Immunosuppression; Protein synthesis inhibitor; Internal medicine; Gastroenterology; Urology; Antibacterial agent; Insulin; Antibiotics; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002367597,0.0001932585,0.0003443003,0.0002285774,0.00003206766,0.00002501556,0.0000387967,0.00006642676,0.0002386138],"category_scores_gemma":[0.00002601235,0.0001686906,0.00005612271,0.0002526132,0.00005978339,0.0001074426,0.00001386561,0.0001512399,0.00002656085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001415986,"about_ca_system_score_gemma":0.00002808868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304157,"about_ca_topic_score_gemma":0.00001683068,"domain_scores_codex":[0.9987978,0.00007243954,0.0003926776,0.0002379708,0.0002521584,0.0002468938],"domain_scores_gemma":[0.9995327,0.0001035138,0.00007333252,0.000113103,0.0000656214,0.0001117027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007162012,0.002292976,0.704732,0.00261569,0.0002400985,0.0007831625,0.003823874,0.0004356983,0.2223088,0.001700473,0.01069767,0.04320755],"study_design_scores_gemma":[0.008470921,0.00004469679,0.9193364,0.00007856866,0.0007474091,0.00004162198,0.00007148362,0.003620832,0.03683143,0.0006062213,0.0298822,0.000268168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990021,0.005509492,0.0001805307,0.001292142,0.0002868161,0.0003150523,0.00005414683,0.00004955241,0.002291204],"genre_scores_gemma":[0.9934532,0.00245283,0.0009278849,0.001592694,0.0005086557,0.00005517386,0.0003242152,0.00002308486,0.0006622479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2146045,"threshold_uncertainty_score":0.6879005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008345942105734102,"score_gpt":0.2544121330132378,"score_spread":0.2460661909075037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}