{"id":"W1986250787","doi":"10.2133/dmpk.21.492","title":"Temporal Decline in Sirolimus Elimination Immediately After Pancreatic Islet Transplantation","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sirolimus; Medicine; Tacrolimus; Pharmacokinetics; Transplantation; Pharmacology; Islet; NONMEM; Immunosuppression; Protein synthesis inhibitor; Internal medicine; Gastroenterology; Urology; Antibacterial agent; Insulin; Antibiotics; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003489467,0.0001954105,0.0007407755,0.0002697707,0.0002935525,0.00065006,0.0002068141,0.0002957791,0.0005911055],"category_scores_gemma":[0.001647979,0.0001486939,0.0003259898,0.0003203105,0.0002225888,0.0003681196,0.0002416939,0.0008897993,0.0001751701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004200836,"about_ca_system_score_gemma":0.0002667313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143766,"about_ca_topic_score_gemma":0.001040484,"domain_scores_codex":[0.99968,0.00007006912,0.00002435745,0.00006618984,0.00009302875,0.00006630463],"domain_scores_gemma":[0.9989649,0.0002579642,0.0004063083,0.00006512176,0.000162651,0.0001430351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007511966,0.0002486552,0.8613643,0.0001255553,0.0001937493,0.00426034,0.00133369,0.001373162,0.08658815,0.0001712215,0.0002330185,0.03659632],"study_design_scores_gemma":[0.00007333918,0.002077804,0.9645819,0.00001112873,0.0001992089,0.004094674,0.0004204243,0.001966839,0.02468795,0.0001238153,0.001729166,0.00003380869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988931,0.0004387875,0.0003577958,0.00002006118,0.000003084654,0.000004478409,0.000029803,0.00001139299,0.0002415008],"genre_scores_gemma":[0.9996029,0.00007557495,0.00008310249,0.00002300795,0.000003944956,0.000002896689,0.00008558278,0.000003986523,0.0001190823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143766,"threshold_uncertainty_score":0.003047884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008345942105734102,"score_gpt":0.2544121330132378,"score_spread":0.2460661909075037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}