{"id":"W1986310612","doi":"10.1002/cncr.11138","title":"A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases","year":2003,"lang":"en","type":"article","venue":"Cancer","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Medicine; Osteoprotegerin; Multiple myeloma; Bone remodeling; Bone resorption; N-terminal telopeptide; Internal medicine; RANKL; Breast cancer; Bone disease; Endocrinology; Urology; Oncology; Gastroenterology; Cancer; Osteoporosis; Osteocalcin; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007775296,0.0001813448,0.000308014,0.00006414617,0.00003705129,0.000008558868,0.00008205379,0.00006046693,0.00009857543],"category_scores_gemma":[0.00006835859,0.0001313071,0.00004375453,0.0002179646,0.00009004148,0.000007360426,0.00003673349,0.00006202333,0.000001118901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001553077,"about_ca_system_score_gemma":0.0001947317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003644706,"about_ca_topic_score_gemma":0.0005522171,"domain_scores_codex":[0.9988733,0.0001248599,0.0002991708,0.0003452839,0.0001348515,0.0002225538],"domain_scores_gemma":[0.9993091,0.000009986069,0.0001436226,0.0003271523,0.0001134997,0.00009668917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004491518,0.004911377,0.970899,0.00005013336,0.0001286592,0.00004085564,0.000178594,0.00002124207,0.009757369,0.00001412914,0.0001947184,0.009312361],"study_design_scores_gemma":[0.05772014,0.004106231,0.8870389,0.00007523747,0.0002206342,0.00003394168,0.001193622,0.00001076468,0.04732243,0.00001296511,0.00174827,0.0005167917],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997431,0.00132785,0.000004633918,0.000006163158,0.0001207815,0.0007388576,0.0003124721,0.000006631573,0.00005155863],"genre_scores_gemma":[0.9994898,0.00002430109,0.00009535154,0.00002410708,0.00001293145,0.0001435383,0.00007617223,0.00002257297,0.0001112572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08386007,"threshold_uncertainty_score":0.5354549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007748233797994043,"score_gpt":0.2434151151753144,"score_spread":0.2356668813773203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}