{"id":"W1986310612","doi":"10.1002/cncr.11138","title":"A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases","year":2003,"lang":"en","type":"article","venue":"Cancer","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Medicine; Osteoprotegerin; Multiple myeloma; Bone remodeling; Bone resorption; N-terminal telopeptide; Internal medicine; RANKL; Breast cancer; Bone disease; Endocrinology; Urology; Oncology; Gastroenterology; Cancer; Osteoporosis; Osteocalcin; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001040001,0.001248807,0.001900375,0.0003852849,0.0003329329,0.0006043605,0.0007861314,0.0009539683,0.002294691],"category_scores_gemma":[0.0006675543,0.0005473982,0.0008936658,0.0003483284,0.00108918,0.0005434039,0.000313211,0.001949788,0.0006161873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006396768,"about_ca_system_score_gemma":0.001410618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007115137,"about_ca_topic_score_gemma":0.001296225,"domain_scores_codex":[0.9996797,0.0001316828,0.00001591101,0.00006494427,0.00004739639,0.00006030791],"domain_scores_gemma":[0.9994063,0.0001076675,0.0001062064,0.00006096408,0.00004356021,0.0002752235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6772996,0.1001188,0.005746484,0.001084837,0.00118683,0.0004188759,0.0003578686,0.002765813,0.1278503,0.000359189,0.002351805,0.08045952],"study_design_scores_gemma":[0.3905945,0.5980835,0.005035783,0.00001467101,0.0002408922,0.0001832673,0.0000280637,0.0005951401,0.003894599,0.00008059911,0.001232861,0.00001613014],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947193,0.001332689,0.0004989672,0.0002489454,0.00008003082,0.001803712,0.0003565777,0.0000874837,0.0008723165],"genre_scores_gemma":[0.9914652,0.001283107,0.00183799,0.0005052824,0.0001266686,0.002270984,0.0009866597,0.00001967041,0.001504481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294691,"threshold_uncertainty_score":0.007676482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007748233797994043,"score_gpt":0.2434151151753144,"score_spread":0.2356668813773203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}