{"id":"W1986311213","doi":"10.1161/hypertensionaha.109.149344","title":"Role of Phosphoinositide 3-Kinase α, Protein Kinase C, and L-Type Ca<sup>2+</sup>Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility","year":2010,"lang":"en","type":"article","venue":"Hypertension","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto; University of Alberta; St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Internal medicine; Endocrinology; Contractility; Angiotensin II; Protein kinase C; NADPH oxidase; Inotrope; Phospholipase C; Protein kinase A; Biology; Chemistry; Kinase; Receptor; Medicine; Cell biology; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003117982,0.000174525,0.0005899636,0.00009590603,0.000162282,0.000004042262,0.00004863915,0.0001783882,0.0000220266],"category_scores_gemma":[0.0007194954,0.0001246434,0.0001466909,0.0002049666,0.0002298373,0.00005715845,0.00006131878,0.000575886,0.00000398872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000021506,"about_ca_system_score_gemma":0.00008074346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008270983,"about_ca_topic_score_gemma":0.00001975582,"domain_scores_codex":[0.9988176,0.0001357593,0.0003140067,0.0002808217,0.0002001056,0.0002517246],"domain_scores_gemma":[0.9987835,0.0003145801,0.0001253253,0.0004346184,0.0002505108,0.00009150209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008204316,0.0002068867,0.0008298283,0.00002623986,0.00005205209,0.00004212754,0.0004704593,0.0003416725,0.9950691,0.00009046207,0.0002981139,0.001752558],"study_design_scores_gemma":[0.001645165,0.0008541427,0.05576609,0.0001426953,0.00016912,0.0001525429,0.0006612274,0.01523419,0.9240633,0.0001576977,0.0009593445,0.0001944455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976422,0.0003195637,6.488306e-7,0.001047725,0.0001099942,0.0006893905,0.00003387495,0.00002253593,0.0001341082],"genre_scores_gemma":[0.9991575,0.00004995937,0.0001729085,0.0003287486,0.0001680729,0.00001682868,0.00004571927,0.00001911041,0.00004117121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07100584,"threshold_uncertainty_score":0.5082808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718508780605691,"score_gpt":0.2453470312687611,"score_spread":0.2281619434627042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}