{"id":"W1986315918","doi":"10.1016/j.gpb.2013.04.003","title":"Leveraging Metabolomics to Assess the Next Generation of Temozolomide-Based Therapeutic Approaches for Glioblastomas","year":2013,"lang":"en","type":"review","venue":"Genomics Proteomics & Bioinformatics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Université de Moncton","funders":"Brain Tumour Foundation of Canada; Beatrice Hunter Cancer Research Institute","keywords":"Temozolomide; Glioblastoma; Metabolomics; Computer science; Computational biology; Medicine; Cancer research; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008871988,0.0008427155,0.002447502,0.0006481096,0.0002525879,0.0002761864,0.000572947,0.0004954258,0.00001076487],"category_scores_gemma":[0.0001315299,0.0005372012,0.001044268,0.0005665525,0.0001169721,0.0001697909,0.0001666354,0.0004033947,0.00007164575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005969277,"about_ca_system_score_gemma":0.001241509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001310043,"about_ca_topic_score_gemma":0.00000453477,"domain_scores_codex":[0.9964999,0.0001035476,0.001985953,0.0004348624,0.00036654,0.0006091864],"domain_scores_gemma":[0.9963734,0.0003900212,0.001459073,0.001241379,0.0003076183,0.0002284857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006356061,0.0003082859,0.000008884024,0.01554701,0.001304634,0.000001609713,0.0006176897,0.0008530193,0.0005259784,0.001580428,0.000542026,0.9786469],"study_design_scores_gemma":[0.002590858,0.0009654716,0.000005651648,0.003818594,0.007833674,0.0001295789,0.0004327661,0.1510277,0.009012198,0.000243086,0.8227104,0.001230011],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003297236,0.897365,0.07250892,0.0004553747,0.0004923445,0.02534571,0.0003233489,0.00007665444,0.0001354622],"genre_scores_gemma":[0.000447299,0.7147804,0.2774211,0.0005715212,0.0003642181,0.005280681,0.0008990081,0.0001921295,0.00004360314],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9774169,"threshold_uncertainty_score":0.9997079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3212008833620413,"score_gpt":0.3379869372871627,"score_spread":0.01678605392512139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}