{"id":"W1986328966","doi":"10.1074/jbc.m213164200","title":"Three-dimensional Localization of Divergent Region 3 of the Ryanodine Receptor to the Clamp-shaped Structures Adjacent to the FKBP Binding Sites","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Fondation pour la Recherche Médicale; Alberta Heritage Foundation for Medical Research; Muscular Dystrophy Association; Canadian Institutes of Health Research; Uehara Memorial Foundation; New York State Department of Health; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Green fluorescent protein; Ryanodine receptor 2; Chemistry; Biophysics; Crystallography; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008497886,0.0002575149,0.0002289782,0.0001335015,0.0002089556,0.0003202,0.0002924011,0.0003213311,0.001554038],"category_scores_gemma":[0.0001981821,0.0001604825,0.0007391569,0.000140813,0.0002298632,0.0002231647,0.000313071,0.000639192,0.0009097985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004857444,"about_ca_system_score_gemma":0.0003201734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544786,"about_ca_topic_score_gemma":0.001415073,"domain_scores_codex":[0.999928,0.000007616715,0.000004494783,0.00002521075,0.00001689952,0.00001777142],"domain_scores_gemma":[0.9998574,0.00002050086,0.00004798195,0.00001588589,0.00002111686,0.00003704651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248212,0.00001030425,0.000415287,0.00002768568,0.000006649203,0.0001965177,0.00003293134,0.0001272528,0.9979597,0.0002451577,0.00006491933,0.0007888046],"study_design_scores_gemma":[0.00005262914,0.0002062226,0.06513546,0.00003519648,0.00005305608,0.002635085,0.0002358669,0.006028583,0.9170156,0.0004975383,0.008055046,0.00004983653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891855,0.0005946329,0.008582584,0.000111296,0.00002886757,0.00001419593,0.0003675301,0.0000688037,0.001046649],"genre_scores_gemma":[0.9898783,0.0003206367,0.006322967,0.0001409765,0.00001018873,0.00002013581,0.001222272,0.00003467381,0.002049905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001554038,"threshold_uncertainty_score":0.005198777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923877002934132,"score_gpt":0.2453213418191657,"score_spread":0.2160825717898244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}