{"id":"W1986332257","doi":"10.1038/sj.jid.5701153","title":"Correlation between SPINK5 Gene Mutations and Clinical Manifestations in Netherton Syndrome Patients","year":2007,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Kallikrein; Proteases; Serine protease; Biology; Molecular biology; Protease; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006506153,0.00009595973,0.0002157144,0.0001738427,0.00005547509,0.000007220928,0.00009486933,0.0002455564,0.000005209714],"category_scores_gemma":[0.0006377636,0.00008663099,0.00006197274,0.0001198021,0.0005135823,0.0000101404,0.00004784482,0.0002982658,0.000004770114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001688268,"about_ca_system_score_gemma":0.0001087104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005884541,"about_ca_topic_score_gemma":0.00003480574,"domain_scores_codex":[0.9985886,0.0003132083,0.0006480979,0.0001523777,0.0001040474,0.000193629],"domain_scores_gemma":[0.9990476,0.0001758054,0.000310777,0.00009056813,0.0002290507,0.0001462395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005011263,0.00007988364,0.9833618,0.000006720929,0.00008622891,0.0003654751,0.0001115922,0.00001512777,0.01490409,0.0000776557,0.0001366725,0.0008046136],"study_design_scores_gemma":[0.001151014,0.0004946999,0.9600617,0.00001623518,0.00002500935,0.002264269,0.0001265495,0.00003876873,0.03457528,0.0009177724,0.0002381956,0.00009053864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965327,0.000276045,0.002494198,0.0003435087,0.0001160491,0.0001185628,0.000006345742,0.000001898466,0.0001107399],"genre_scores_gemma":[0.9980017,0.00009624554,0.001567841,0.0001319509,0.00006519217,0.000001469228,0.0001002059,0.000009319676,0.00002608018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02330016,"threshold_uncertainty_score":0.3532709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847785820233205,"score_gpt":0.3337374383969979,"score_spread":0.3052595801946659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}