{"id":"W1986332628","doi":"10.1016/j.bbrc.2007.02.100","title":"Activation of LFA-1 by ionomycin is independent of calpain-mediated talin cleavage","year":2007,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ionomycin; Calpain; Cell biology; Chemistry; Biology; Biochemistry; Intracellular; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007245604,0.00008827206,0.000128725,0.00007928367,0.0001002064,0.000008741434,0.0002892709,0.0001859992,0.0000143613],"category_scores_gemma":[0.0004133537,0.00007751423,0.0000687223,0.0003049199,0.0006790672,0.00000599768,0.0002840531,0.0002131327,0.000003729823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002293072,"about_ca_system_score_gemma":0.00006487423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001091412,"about_ca_topic_score_gemma":0.000004989993,"domain_scores_codex":[0.9988595,0.0001295577,0.0002966043,0.0002137327,0.0003126813,0.0001878938],"domain_scores_gemma":[0.9986535,0.000217027,0.00009280982,0.00059583,0.000312437,0.000128422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001563081,0.0003556452,0.0003306468,0.00002874014,0.00002503072,5.261375e-8,0.00004370965,1.164762e-7,0.9894295,0.0004734127,0.006743889,0.002412967],"study_design_scores_gemma":[0.0003366067,0.0001826426,0.002914544,0.00002550277,0.000005705079,6.119598e-7,0.0001186379,0.0001666318,0.9833032,0.0002120006,0.01265208,0.00008187158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957335,0.0004276149,0.001804623,0.001034319,0.00001169635,0.0002610532,0.00006316582,0.000007440049,0.0006565691],"genre_scores_gemma":[0.9984102,0.0002929769,0.0004371358,0.00007065829,0.00004982793,0.00001566705,0.0004431955,0.000008858951,0.0002715254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006126321,"threshold_uncertainty_score":0.3160939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602746664809977,"score_gpt":0.3440448515707714,"score_spread":0.3080173849226717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}