{"id":"W1986362740","doi":"10.1038/sj.cdd.4401568","title":"Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes","year":2005,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute; McGill University; Hôpital Saint-Luc","funders":"Canadian Institutes of Health Research; Medical Research Council; Alzheimer's Society","keywords":"Jurkat cells; Caspase; Cell biology; Apoptosis; Programmed cell death; Intrinsic apoptosis; Notch signaling pathway; Cleavage (geology); Ankyrin repeat; Death domain; Biology; T cell; Chemistry; Molecular biology; Signal transduction; Immunology; Biochemistry; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006049953,0.0001297323,0.0001342,0.0000831085,0.0001385245,0.0001029187,0.00006843733,0.00007211971,0.0001565356],"category_scores_gemma":[0.00002902643,0.0001230364,0.00003065317,0.000125639,0.000021137,0.0002550859,0.0000353864,0.00009959636,0.00004821123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006079293,"about_ca_system_score_gemma":0.00001156782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007621759,"about_ca_topic_score_gemma":0.000008273284,"domain_scores_codex":[0.9990962,0.00006744128,0.0001445169,0.0003176726,0.0001413776,0.0002327873],"domain_scores_gemma":[0.9996606,0.00006934593,0.00007370862,0.0001034712,0.000009029456,0.0000838476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003270653,0.0001230063,0.006527545,0.0000216464,0.00000105464,0.000002247136,0.0003866227,0.00001441048,0.9831808,0.00002717972,0.0001644884,0.009518283],"study_design_scores_gemma":[0.0007725382,0.0000285117,0.01103189,0.00001671363,0.000008494531,0.000001963654,0.00001806402,0.02822722,0.9594753,0.00003642831,0.0002405021,0.0001424069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983483,0.0001138485,0.0004643022,0.00007314189,0.00008463551,0.0001238433,0.000008477855,0.00004585052,0.0007376083],"genre_scores_gemma":[0.9991402,0.0001922064,0.00006281981,0.0002669681,0.00003670586,0.000003110422,0.000007485387,0.00001592646,0.0002745452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02821281,"threshold_uncertainty_score":0.5017279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859127650445157,"score_gpt":0.2362900009402994,"score_spread":0.2176987244358479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}