{"id":"W1986362740","doi":"10.1038/sj.cdd.4401568","title":"Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes","year":2005,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute; McGill University; Hôpital Saint-Luc","funders":"Canadian Institutes of Health Research; Medical Research Council; Alzheimer's Society","keywords":"Jurkat cells; Caspase; Cell biology; Apoptosis; Programmed cell death; Intrinsic apoptosis; Notch signaling pathway; Cleavage (geology); Ankyrin repeat; Death domain; Biology; T cell; Chemistry; Molecular biology; Signal transduction; Immunology; Biochemistry; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003380323,0.0003645617,0.0004867994,0.0004006477,0.0003035033,0.0008009178,0.0004920362,0.0005884161,0.002903582],"category_scores_gemma":[0.0003435574,0.0002704529,0.0003699489,0.0002335354,0.0003535589,0.0004748697,0.0002960121,0.001507065,0.0007280702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005182215,"about_ca_system_score_gemma":0.0002865682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003301861,"about_ca_topic_score_gemma":0.0005527957,"domain_scores_codex":[0.9994614,0.0001031507,0.00005623851,0.00006548653,0.0001169553,0.000196745],"domain_scores_gemma":[0.9996753,0.00008126712,0.00007172879,0.00005253819,0.00003284763,0.00008636167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007341277,0.00004454363,0.0002972464,0.00006406171,0.00001774309,0.0001739199,0.00003249537,0.0001024387,0.9962019,0.000390151,0.00008739837,0.001853871],"study_design_scores_gemma":[0.0000827171,0.0002552762,0.003000079,0.00001138141,0.00002300345,0.001046633,0.00008757178,0.0008228731,0.9929396,0.0002076577,0.001516372,0.000006788001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942761,0.001954461,0.001447511,0.0001448322,0.00003247777,0.00001810557,0.0002974969,0.0000562104,0.001772783],"genre_scores_gemma":[0.9969109,0.0004616628,0.0006771116,0.00003567663,0.000008949899,0.00001775101,0.0002882748,0.00001118853,0.001588723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002903582,"threshold_uncertainty_score":0.009713471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859127650445157,"score_gpt":0.2362900009402994,"score_spread":0.2176987244358479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}