{"id":"W1986376155","doi":"10.1016/j.jbiotec.2005.03.004","title":"A multiwavelength fluorescence probe: Is one probe capable for on-line monitoring of recombinant protein production and biomass activity?","year":2005,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Canada Research Chairs","keywords":"Pichia pastoris; Green fluorescent protein; Fluorescence; Bioreactor; Yeast; Tryptophan; Recombinant DNA; NAD+ kinase; Chemistry; Biomass (ecology); Fluorescence spectroscopy; Biochemistry; In situ; Biology; Chromatography; Biophysics; Enzyme; Botany; Optics; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001985321,0.0001321023,0.000225926,0.0001496418,0.00007718292,0.000009751428,0.0001313783,0.0002903686,0.000003226879],"category_scores_gemma":[0.0002694166,0.0001105204,0.00009026602,0.0001057974,0.0001089854,0.00001400808,0.0000619109,0.0001690385,5.315329e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002664539,"about_ca_system_score_gemma":0.00006832288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009566791,"about_ca_topic_score_gemma":0.000004206352,"domain_scores_codex":[0.9991144,0.00002833353,0.0003116652,0.0002457456,0.0001104862,0.0001893616],"domain_scores_gemma":[0.9991103,0.000006496847,0.0004327245,0.0002211704,0.0001739596,0.00005533909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005170327,0.0004794102,0.0003219794,0.0001093022,0.00006524139,9.432398e-7,0.00002777749,0.00001938618,0.9705322,0.00002927723,0.0004516315,0.02744579],"study_design_scores_gemma":[0.0007171984,0.003383603,0.0002873955,0.0002361433,0.00002324834,0.00004860158,0.00003033293,0.00008342859,0.9925084,0.0002369973,0.00232731,0.0001173408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993345,0.0006185476,0.002600256,0.002602954,0.0003222834,0.0004883641,0.00000771172,0.00001069927,0.000004144102],"genre_scores_gemma":[0.9851964,0.0004869491,0.01365322,0.000017883,0.0004048481,0.00003677617,0.000001229061,0.00001643217,0.0001862879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02732845,"threshold_uncertainty_score":0.450689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133749525783132,"score_gpt":0.2790118972033261,"score_spread":0.2576744019454947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}